Change in psychosocial functioning and quality of life of patients with body dysmorphic disorder treated with fluoxetine: a placebo-controlled study

Psychosomatics
Katharine A Phillips, Steven A Rasmussen

Abstract

In a 12-week placebo-controlled study of fluoxetine in the treatment of body dysmorphic disorder, the authors investigated change in psychosocial functioning and mental health-related quality of life in 60 subjects. The subjects were assessed with the LIFE-RIFT (a measure of impaired functioning), Social and Occupational Functioning Scale (SOFAS), and Medical Outcomes Study 36-Item Short-Form Health Survey (SF-36) before and after receiving fluoxetine or placebo. At baseline, the patients had impaired psychosocial functioning and markedly poor mental health-related quality of life. Compared to placebo, fluoxetine was associated with significantly greater improvement in LIFE-RIFT and SOFAS scores and with improvement on the mental health subscale of the SF-36 that approached significance. Decrease in the severity of body dysmorphic disorder, as measured by the Yale-Brown Obsessive Compulsive Scale Modified for Body Dysmorphic Disorder, was significantly correlated with improvement in functioning and quality of life.

References

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Citations

Sep 4, 2012·CNS Spectrums·Waguih William IsHakKimberly M Ponton
Nov 15, 2006·Plastic and Reconstructive Surgery·Canice E CrerandDavid B Sarwer
Mar 4, 2014·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Brooke CollinsSabine Girod
Jul 1, 2010·Psychiatric Annals·Katharine A Phillips
Oct 31, 2008·Comprehensive Psychiatry·Elizabeth R DidieKatharine A Phillips
May 18, 2006·Behavioral Sciences & the Law·Douglas A Smith, Peter F Buckley
Sep 24, 2005·Comprehensive Psychiatry·Katharine A PhillipsMaria E Pagano
Apr 2, 2008·Journal of Psychiatric Research·Katharine A PhillipsRobert L Stout
Feb 1, 2017·Clinical Psychopharmacology and Neuroscience : the Official Scientific Journal of the Korean College of Neuropsychopharmacology·Sourav Khanra, Sourav Das
Aug 14, 2018·Current Neuropharmacology·Antonio Del CasaleMaurizio Pompili
Jan 23, 2009·The Cochrane Database of Systematic Reviews·Jonathan C IpserDan J Stein
Jul 19, 2018·Endocrine·M VermalleF Castinetti
Jun 6, 2009·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·Arun V RavindranNeil A Rector
May 12, 2012·Journal of Child Sexual Abuse·Gerard A SchaeferChristian Bahls

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