Change in rates of prenatal tests for chromosomal abnormality over a 12-year period in women of advanced maternal age

Obstetrics & Gynecology Science
Soo Min KimMin Hyoung Kim

Abstract

In 2007, the American College of Obstetricians and Gynecologists (ACOG) recommended that all pregnant women be offered screening or diagnostic tests for chromosomal abnormalities regardless of their age. Noninvasive prenatal testing (NIPT) for common chromosomal aneuploidies was introduced as a screening test in case of high-risk pregnancies. We assessed the rates of prenatal tests in women aged 35 years and older. A retrospective study was conducted to compare the rates of amniocentesis, chorionic villus sampling (CVS), serum screening, and NIPT from January 2005 through March 2017 in women aged 35 years and older. We divided the initial 12 months after NIPT introduction into 4-month intervals, beginning in April 2016 through March 2017. The rates of amniocentesis were 56% before the ACOG statement, 38% between the ACOG statement and NIPT introduction, and 10% after NIPT introduction (P=0.001). The rates of CVS during the same periods were 0.5%, 2.1%, and 4.3% (P=0.016), respectively. The rates of serum screening were 44.2%, 61.3%, and 55.1% (P=0.049), respectively. During the 3 quarters after NIPT introduction, the rates of amniocentesis were 16.2%, 12.3%, and 7.3% (P=0.002), respectively; the rates of serum screening were 62...Continue Reading

References

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Jun 24, 2014·American Journal of Obstetrics and Gynecology·Sebastian LarionAlfred Z Abuhamad

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Citations

Jan 27, 2019·Prenatal Diagnosis·Filomena Giulia SileoAmarnath Bhide
Jun 18, 2021·The Kurume Medical Journal·Toshiyuki YoshizatoKimio Ushijima

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