Change in sexual risk behaviour after 6 months of pre-exposure prophylaxis use: results from the Amsterdam pre-exposure prophylaxis demonstration project

AIDS
Elske HoornenborgAmsterdam PrEP Project team in the HIV Transmission Elimination Amsterdam Initiative

Abstract

HIV pre-exposure prophylaxis (PrEP) use may lead to higher STI incidence via behavioural risk compensation. We examined changes in sexual behaviour between baseline and 6 months after PrEP initiation among MSM and transgender women (TGW). Prospective, open-label demonstration study at a large sexually transmitted infection (STI) clinic in Amsterdam, the Netherlands. Participants answered questions about sexual behaviour in the preceding 3 months, including number of anal sex partners and frequency of anal sex with and without condom by partner type and were tested for STI. Sexual behaviour at baseline was compared with 6 months after PrEP initiation using Wilcoxon signed rank tests. Logistic regression was used to identify factors associated with an increase in receptive condomless anal sex acts (rCASa) with casual partners. Data were available for 328 (99%) MSM and 2 (1%) TGW. The number of receptive and insertive condomless anal sex acts (CASa) increased (baseline: median 11, interquartile range 4-23; 6 months: median 14, interquartile range 6-26, P < 0.001), whereas the number of anal sex partners (P = 0.2) and anal sex acts (P = 0.8) remained unchanged. Prevalence of STI was stable. Older age, prior engagement in chemsex, r...Continue Reading

References

Apr 22, 2010·International Journal of Epidemiology·Rebecca F BaggaleyMarie-Claude Boily
Sep 4, 2015·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jonathan E VolkC Bradley Hare
Dec 2, 2015·The New England Journal of Medicine·Jean-Michel MolinaUNKNOWN ANRS IPERGAY Study Group
Nov 17, 2016·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Julia L MarcusJonathan E Volk
Jul 14, 2017·The Lancet Infectious Diseases·Magnus UnemoChristopher K Fairley
Apr 1, 2018·Journal of the International AIDS Society·Elske HoornenborgUNKNOWN Amsterdam PrEP Project team in the HIV Transmission Elimination AMsterdam Initiative

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Citations

Jan 8, 2019·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Lisa B Hightow-WeidmanDarrell Wheeler
May 17, 2019·AIDS Patient Care and STDs·Sarit A Golub, Julie E Myers
Jun 4, 2019·Journal of Sex & Marital Therapy·Carmina R FumazBonaventura Clotet
Oct 8, 2019·Current Opinion in HIV and AIDS·Godelieve J de BreeUNKNOWN HIV Transmission Elimination AMsterdam (H-TEAM) Initiative
Jun 5, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J Carlo HojillaJonathan E Volk
Jul 14, 2020·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Randy StalterUNKNOWN Partners Demonstration Project Team
Jun 23, 2019·Current Infectious Disease Reports·Victoria E PowellDouglas S Krakower
Jul 13, 2019·F1000Research·Sarah J Coates, Kieron S Leslie
Jun 20, 2020·AIDS·Kayla StankevitzFern Terris-Prestholt
Feb 9, 2021·PloS One·Carlos IniestaUNKNOWN Spanish Working Group for PrEP
Apr 15, 2021·Der Nervenarzt·Marcus GertzenTobias Rüther
May 29, 2021·Enfermedades infecciosas y microbiología clínica·Montserrat LagunoJosep Mallolas
Jul 17, 2021·AIDS·Albert Jan van HoekUNKNOWN Amsterdam PrEP Project Team in the HIV Transmission Elimination Amsterdam (H-TEAM) Initiative
Jul 7, 2021·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Vita W JongenUNKNOWN Amsterdam PrEP Project team in the HIV Transmission Elimination Amsterdam Initiative
Oct 2, 2021·AIDS Education and Prevention : Official Publication of the International Society for AIDS Education·Nick GaglianoRod Knight

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Software Mentioned

STATA
AMPrEP

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