Change in the expression of NPY receptor subtypes Y1 and Y2 in central and peripheral neurons related to the control of blood pressure in rats following experimental hypertension

Neuropeptides
Emerson F CoelhoDébora R Fior-Chadi

Abstract

Neuropeptide Y (NPY) is known to participate in central mechanisms of blood pressure control. However, variations on the expression of its receptors in response to a hypertensive challenge are not well defined, specially when considering that Y1 and Y2 often mediate opposite responses. In this study we have employed in situ hybridization to analyze changes in mRNA expression of NPY receptor subtypes Y1 and Y2 in the nucleus tractus solitarii (NTS), paraventricular nucleus of the hypothalamus (PVN) and petrosal and nodose ganglions 2 h, 3 and 7 days after aortic coarctation induced hypertension. Quantification by image analysis showed significant differences between sham-operated and aortic-coarcted hypertensive rats. Y1 receptor mRNA expression was increased (39%) in petrosal ganglion, 3 days after surgery. Y2 receptor mRNA expression was increased (143%) in the NTS of hypertensive compared with sham rats 2 h after surgery. Y2 receptor mRNA was decreased (62%) in the nodose ganglion of hypertensive compared with sham rats 2 h after surgery. No change was seen in Y1 and Y2 mRNA expression in the PVN in any analyzed period. The data suggest that NPY Y1 and Y2 receptors might participate in the mechanisms involved in the establish...Continue Reading

References

Jan 1, 1991·Experimental Brain Research·M F Czyzyk-KrzeskaD E Millhorn
Oct 1, 1986·Physiology & Behavior·J P Kroon, A L Riley
Apr 16, 1998·Hypertension·C M dos SantosL C Michelini
May 11, 1999·Brain Research. Brain Research Protocols·M Erdtmann-VourliotisV Höllt
Sep 26, 2001·Autonomic Neuroscience : Basic & Clinical·Z LénárdM Kollai
Feb 6, 2004·Progress in Neurobiology·R A L Dampney, J Horiuchi

❮ Previous
Next ❯

Citations

Jul 16, 2008·Journal of Hypertension·Nicola SantoroLaura Perrone
Jun 11, 2011·Neuropeptides·Katarzyna Kaczyńska, Małgorzata Szereda-Przestaszewska
Jul 17, 2015·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Yongqiao ZhouChunyu Zeng
Jul 28, 2016·Molecular and Cellular Endocrinology·B MikuláškováJ Kuneš
Aug 18, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Niels VrangPhilip Just Larsen
Feb 15, 2019·Experimental Biology and Medicine·Roongrit KlinjampaTripop Lertbunnaphong
Mar 16, 2013·Physiological Research·K Kaczyńska, M Szereda-Przestaszewska

❮ Previous
Next ❯

Related Concepts

Related Feeds

Aortic Coarctation

Aortic coarctation is a congenital condition characterized by narrowing of the aorta. Discover the latest research on this disease here.