Change in the synthesis rates of ocular retinoic acid and scleral glycosaminoglycan during experimentally altered eye growth in marmosets.

Investigative Ophthalmology & Visual Science
David TroiloJody A Summers Rada

Abstract

The purpose of this study was to examine the possibility that all-trans-retinoic acid (RA) in the eye is a signal related to changes in scleral extracellular matrix in a primate model of postnatal eye growth. Juvenile marmosets (Callithrix jacchus) were divided into two experimental groups based on their response to monocular deprivation with diffusers: group 1, treated eyes becoming longer than fellow control eyes (n = 8), and group 2, treated eyes becoming shorter than control eyes (n = 7). Eyes were enucleated, dissected, and assayed for changes in the rates of scleral glycosaminoglycan (GAG) synthesis and ocular RA synthesis. The rate of incorporation of (35)SO4 into CPC-precipitable GAG in scleras was taken as a measure of the rate of synthesis of proteoglycans. In the same eyes the rate of RA synthesis in vivo was measured separately in the retina and the choroid/RPE (choroid with RPE attached) by HPLC. The effect of RA on the rate of scleral GAG synthesis was also examined in tissue-cultured pieces of sclera from additional marmosets. Induced changes in vitreous chamber length in diffuser-treated eyes correlated inversely with the rate of scleral GAG synthesis (P < 0.05) and directly correlated with the rate of RA synthe...Continue Reading

Citations

Dec 24, 2008·Optometry and Vision Science : Official Publication of the American Academy of Optometry·David TroiloElise Harb
Nov 11, 2009·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Junfeng MaoQian Tan
Jan 25, 2011·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Donald O Mutti, Amanda R Marks
Jan 16, 2016·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Frank Schaeffel, Marita Feldkaemper
Mar 24, 2011·Biochemical and Biophysical Research Communications·Junbo Rong, Shuangzhen Liu
Jan 2, 2010·Progress in Retinal and Eye Research·Debora L Nickla, Josh Wallman
Mar 27, 2013·Experimental Eye Research·Jody A Summers
Mar 1, 2011·Experimental Eye Research·Jody A Summers Rada, Lindsey R Hollaway
Mar 31, 2015·Experimental Eye Research·Angelica R Harper, Jody A Summers
Apr 20, 2014·Experimental Eye Research·Li HeThomas T Norton
Dec 3, 2008·Experimental Eye Research·Andrew Ian JoblingNeville Anthony McBrien
Nov 11, 2008·Vision Research·Marcus H C Howlett, Sally A McFadden
Dec 7, 2016·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Chen-Wei PanSeang-Mei Saw
Nov 3, 2016·Developmental Neurobiology·Samuel U NummelaJude F Mitchell
Apr 13, 2017·Journal of Tissue Engineering and Regenerative Medicine·Kosei ShinoharaKyoko Ohno-Matsui
Jul 6, 2014·Journal of Child Neurology·Marcella NebbiosoNicola Pescosolido
Dec 7, 2018·Investigative Ophthalmology & Visual Science·Miaozhen PanXiangtian Zhou
Mar 1, 2019·Investigative Ophthalmology & Visual Science·David TroiloLyndon Jones
Nov 22, 2019·Journal of Zhejiang University. Science. B·Qing-Qing XiaJie Li
Mar 17, 2016·Experimental Biology and Medicine·Junfeng MaoChunyan Fu
Aug 12, 2020·Vestnik oftalmologii·E P TaruttaN A Tarasova
Jul 13, 2016·The Journal of Biological Chemistry·Jody A SummersChristopher M West
Aug 22, 2020·Translational Vision Science & Technology·Fletcher J NgSeyhan Yazar
Jan 25, 2011·Expert Review of Ophthalmology·Prema Ganesan, Christine F Wildsoet
Jan 1, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Wen-Yi WangI-Jong Wang
Sep 23, 2020·Experimental Eye Research·Jody A SummersFalk Schroedl
Jul 7, 2021·Experimental Eye Research·Jody A SummersAndrei V Tkatchenko

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.