Change in vision after retinal pigment epithelium tear following the use of anti-VEGF therapy for age-related macular degeneration

Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie
Shane R DurkinJagjit Gilhotra

Abstract

We investigated visual acuity outcomes and their associations in the setting of retinal pigment epithelium tear (RPET) following the use of anti-vascular endothelial growth factor (anti-VEGF) agents. This retrospective review included all patients treated for neovascular age-related macular degeneration (AMD) with an anti-VEGF agent who subsequently developed an RPET. All patients who developed an RPET were identified and outcome measures data were recorded and analysed. The main outcome measures were best corrected visual acuity (BCVA) and spectral domain optical coherence tomography characteristics. Among the 14 participants identified, a subfoveal RPET was associated with the loss of one or more lines of vision from baseline (p = 0.03). There was no association between the size of the RPET and BCVA at the time of the RPET or final BCVA. The development of a disciform scar was associated both with a BCVA at the time of the RPET of < 6/24 (p = 0.02) and a final BCVA of < 6/24 (p = 0.02). Ongoing treatment with an anti-VEGF agent following an RPET saw five patients (35.7 %) have an improvement in their BCVA and all patients maintained their BCVA following the RPET with ongoing anti-VEGF treatment. Visual decline following an RP...Continue Reading

References

Oct 15, 1991·American Journal of Ophthalmology·L A LevinT Topping
Dec 1, 1990·Archives of Ophthalmology·J I Lim, S Lam
Dec 1, 1990·Archives of Ophthalmology·N M BresslerD Yarian
Jun 1, 1985·The British Journal of Ophthalmology·A G CasswellA C Bird
Jun 1, 1981·The British Journal of Ophthalmology·A HoskinK Sehmi
Aug 3, 2001·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·C H Meyer, C A Toth
Oct 6, 2006·The New England Journal of Medicine·Philip J RosenfeldUNKNOWN MARINA Study Group
Oct 6, 2006·The New England Journal of Medicine·David M BrownUNKNOWN ANCHOR Study Group
Oct 25, 2006·European Journal of Ophthalmology·P KaradimasE A Bouzas
Jul 27, 2007·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·D KookM W Ulbig
Jan 29, 2009·Retina·Bradley T SmithRajendra S Apte
May 7, 2009·Acta Ophthalmologica·Julie GueudryGérard Brasseur
Nov 26, 2009·Ophthalmic Surgery, Lasers & Imaging : the Official Journal of the International Society for Imaging in the Eye·Iris MorozAmir Alhalel
May 12, 2010·Retina·David SarrafAtul Jain
Jul 10, 2013·Clinical Ophthalmology·Masaaki SaitoTetsuju Sekiryu

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