PMID: 1206734Nov 1, 1975Paper

Change of antigenic expression on rat tumor cells after their transplantation

Journal of the National Cancer Institute
E GotohdaT Kawamura

Abstract

Antigenic expression of 3-methylcholanthrene-induced transplantable fibrosarcoma KMT-17 cells was investigated in relation to days after ip transplantation. Cytotoxicity tests with antiserum against tumor-associated surface antigen of KMT-17 cells revealed that cytotoxic sensitivity and absorbing capacity decreased after transplantation, but they increased when other normal rats were given transplants of tumor cells. A decrease in the sensitivity was observed when immunosuppressively irradiated rats were given tumor transplants. Tumor cell density in the abdominal cavities of rats directly and absorbing capacity of KMT-17 cells to antiserum against the histocompatibility antigen did not change after transplantation. The possible mechanisms of antigenic change of KMT-17 cells were discussed.

Citations

Jul 29, 1998·International Journal of Cancer. Journal International Du Cancer·I OhizumiT Mayumi

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