Change of brain structure imaging of long-term withdrawal of methamphetamine-dependent patients

Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences
Zhixue ZhangZhifeng Kou

Abstract

To explore the characteristics of brain structure in patients with long-term withdrawal of methamphetamine-dependence.
 Methods: A total of 44 patients with withdrawal of methamphetamine-dependent for more than 14 months were recruited, who met the diagnostic criteria for substance dependence in the fifth edition of the American Mental Disorders Diagnostic and Statistical Manual (DSM-V), and 40 healthy subjects were used as the control. In addition to the general scale of drug-relevant survey, the subjects received the 3.0T magnetic resonance high-resolution scan. The voxel-based morphometric measurements for the subject's brain gray volume were conducted.
 Results: There was no significant difference in age, education, smoking and alcohol consumption between the methamphetamine-dependent withdrawal group and the control group (P>0.05). The volumes for the bilateral cerebellum, the left side of temporal gyrus and the right side of the lingual gyrus in the methamphetamine-dependent withdrawal group were increased than those in the control group. The volumes for the bilateral lingual gyrus and bilateral cuneus in the methamphetamine-dependent withdrawal group were decreased than those in the control group. The volumes of left of ...Continue Reading

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