Change of cholinergic transmission and memory deficiency induced by injection of beta-amyloid protein into NBM of rats

Science in China. Series C, Life Sciences
X MaZ Mei

Abstract

The change of cholinergic transmission of beta-amyloid protein (beta-AP) treated rats was studied by intracerebral microdialysis sampling combined with HPLC analysis. beta-AP(1-40) was injected into nucleus basalis magnocellularis (NBM). Passive avoidance response test (step-down test) and delayed alternation task were used for memory testing. The impairment of memory after injection of beta-AP(1-40) into NBM exhibited mainly the deficiency of short-term working memory. One week after injection of beta-AP(1-40) the release of acetylcholine (ACh) from frontal cortex of freely-moving rats decreased significantly, and the response of cholinergic nerve ending to the action of high [K(+)] solution was rather weak. In control animals the percentage of increase of ACh-release during behavioral performance was 57%, while in beta-AP(1-40)-treated rats it was 34%. The temporary increase of the ACh-release of the rat put into a new place was also significantly diminished in beta-AP(1-40) -treated rats. The results show that the injection of beta-AP(1-40) into NBM impairs the cholinergic transmission in frontal cortex, and the impairment of cholinergic transmission may be the main cause of the deficit of working memory.

References

Apr 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·J F FloodE Roberts
Oct 1, 1986·Physiology & Behavior·J P Kroon, A L Riley
Jan 1, 1981·Psychopharmacology·E D CaineS Wehry
Jan 1, 1981·Annual Review of Pharmacology and Toxicology·L R Squire, H P Davis
May 1, 1995·Cerebral Cortex·B E SwartzM Mandelkern
Aug 30, 1994·Proceedings of the National Academy of Sciences of the United States of America·G McCarthyR G Shulman
Aug 18, 1995·Journal of Chromatography. B, Biomedical Applications·T HuangA Heller

❮ Previous
Next ❯

Citations

Jul 24, 2013·International Journal of Peptides·Armando I Gutiérrez-LermaFernando Peña-Ortega
Sep 3, 2008·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Yipeng Cai, Ji-Zeng Du

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.