PMID: 8953415Nov 1, 1996Paper

Change of glutathione S-transferases in the skin by ultraviolet B irradiation

Journal of Dermatological Science
K I SeoS C Park

Abstract

Glutathione S-transferases (GSTs) may play an important role in protecting skin from ultraviolet radiation (UVR). However, the study on the response of GST to UVR is limited at present. We have examined the effects of a single exposure to ultraviolet B (UVB) radiation on GST in cultured human keratinocytes and the epidermis of SKH/hr-1 hairless mice. We have also investigated the changes of skin GST by chronic irradiation of UVB on the hairless mice. Significant decreases in GST activities in vitro and in vivo were observed at 24 h after 30 and 50 mJ/cm2 UVB irradiation. Chronic UVB exposure also caused decrease in GST activities of the skin tissue. However, any changes in mRNA expression or protein amount of GST have not been observed by Northern blot analysis and Western blot analysis after 30 mJ/cm2 UVB irradiation in cultured human keratinocytes, which suggests that mRNA expression and protein amount of GST are not affected by UVB. These results suggest that UVB irradiation results in inhibitory effect on GST activity in the skin.

References

Jan 1, 1991·Journal of Dermatological Science·K HanadaK Sato
Sep 1, 1991·The Journal of Investigative Dermatology·K L BlackerT D Boyer
Apr 1, 1991·Archives of Biochemistry and Biophysics·H X ShenK Sato
Jan 1, 1991·Archives of Dermatological Research·Y HashimotoH Iizuka
Apr 1, 1991·The Journal of Investigative Dermatology·H RazaH Mukhtar
Jun 1, 1991·The Journal of Investigative Dermatology·K HanadaM J Connor
Aug 1, 1990·The Journal of Investigative Dermatology·A KonohanaM Duvic
Jun 1, 1987·Journal of Pharmacobio-dynamics·Y MiyachiY Niwa
Mar 1, 1989·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·T D Boyer
Jan 1, 1989·Free Radical Biology & Medicine·K U Schallreuter, J M Wood
Jan 1, 1989·Annual Review of Biochemistry·C B Pickett, A Y Lu
Nov 1, 1986·The Journal of Investigative Dermatology·L A WheelerN Lowe
Jan 25, 1985·Science·P A Cerutti
Oct 1, 1987·Annals of Internal Medicine·C E CrossD Harman
Aug 1, 1987·Photochemistry and Photobiology·M J Connor, L A Wheeler
Feb 1, 1972·Journal of Medical Microbiology·H HaasT Sacks
Jun 1, 1971·Biochimica Et Biophysica Acta·T K Ray, G V Marinetti
Aug 15, 1984·The Biochemical Journal·T F Slater
Aug 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·C B PickettR G Cameron
Jan 1, 1993·Skin Pharmacology : the Official Journal of the Skin Pharmacology Society·D A VesseyT D Boyer
Mar 1, 1993·The Journal of Investigative Dermatology·Y ShindoL Packer

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Citations

Mar 23, 2006·Occupational and Environmental Medicine·M Saadat, M Farvardin-Jahromi
Feb 6, 2004·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Eric F BernsteinSergey M Ksenzenko
Jul 28, 2006·Photodermatology, Photoimmunology & Photomedicine·Ayca Cordan YaziciAynur Adiguzel
Oct 31, 2009·Clinical and Experimental Dermatology·F GuarneriS P Cannavò
Apr 7, 2011·Biological & Pharmaceutical Bulletin·Alena Rajnochová SvobodováJitka Vostálová
Nov 1, 2020·The Science of the Total Environment·Mário J AraújoMarta S Monteiro

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