Change of steroid receptor expression in the posterior vaginal wall after local estrogen therapy.

European Journal of Obstetrics, Gynecology, and Reproductive Biology
Anne FuermetzKatharina Jundt

Abstract

Little is known about the reaction of the posterior vaginal wall influenced by steroid receptor expression. The aim of our study was to evaluate change of estrogen and progesterone receptor expression in the posterior vaginal wall after local estrogen therapy for vaginal prolapse surgery and to compare this expression with a group of untreated women of same age. Furthermore we examined the steroid receptor expression among untreated women in each period of life. In a prospective clinical study we examined staining intensity and ratio of positive cytoblasts in specimens of vaginal tissue sampled during posterior colporrhaphy and as control group specimens from autopsied corpses to proof the change in steroid receptor expression in treated women after local estrogen therapy compared to treatment-naive women of all ages. We compared 60 premenopausal female corpses to 43 postmenopausal female corpses and 80 postmenopausal women undergoing posterior colporrhaphy to 43 postmenopasusal female corpses. Estrogen-receptor alpha score was significantly higher in the intervention group in basal epithelium (p=0.004), stroma (p≤0.001) and connective tissue (p=0.005). Estrogen-receptor beta score was significantly higher in basal epithelium (...Continue Reading

References

Jun 1, 1997·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·M van HaaftenJ H Thijssen
Oct 27, 2007·Acta Obstetricia Et Gynecologica Scandinavica·Marie Westergren SöderbergGunvor Ekman Ordeberg
Nov 26, 2010·International Urogynecology Journal·Christine Elisabeth SkalaHeinz Koelbl

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Citations

Jul 12, 2018·Menopause : the Journal of the North American Menopause Society·Päivi Rahkola-SoisaloTomi S Mikkola
Jan 10, 2018·International Urogynecology Journal·Iva UrbankovaJan Deprest
Dec 12, 2018·Menopause : the Journal of the North American Menopause Society·Ana Elisa RibeiroAdriana Orcesi Pedro
Apr 18, 2020·Menopause : the Journal of the North American Menopause Society·Ravali A ReddyFrank Z Stanczyk
Sep 4, 2020·Climacteric : the Journal of the International Menopause Society·V M MillerS M Harman
Oct 14, 2021·Scientific Reports·Ling-Ying WuFei-Chi Chuang

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