Change of walking distance in intermittent claudication: impact on inflammation, oxidative stress and mononuclear cells: a pilot study

Clinical Research in Cardiology : Official Journal of the German Cardiac Society
Jörn F DopheideChristine Espinola-Klein

Abstract

Atherosclerosis is a chronic inflammatory process involving the immune system and formation of reactive oxygen species (ROS). We investigated changes of mononuclear blood cells and ROS production in relation to the walking distance of patients with intermittent claudication during home-based exercise training. Forty patients with intermittent claudication were asked to perform a home-based exercise training for a mean time of 12 months. ROS formation was measured using the luminol analogue L-012. Peripheral blood leucocytes [monocytes, polymorphonuclear neutrophils (PMN) and dendritic cells (DC)] were analysed by flow cytometry and analysed for the expression of major inflammatory surface molecules. At follow-up, patients showed an increased walking distance and reduced ROS production upon stimulation with a phorbol ester derivative (PDBu) (p < 0.01). Monocytes changed their inflammatory phenotype towards an increased anti-inflammatory CD14(++)CD16(-) subpopulation (p < 0.0001). Adhesion molecules CD11b, CD11c and TREM-1 on monocytes and PMN decreased (all p < 0.01). On DC expression of HLA-DR, CD86 or CD40 decreased at follow-up. Inflammatory markers like fibrinogen, C-reactive protein or soluble TREM-1 (sTREM-1) decreased ove...Continue Reading

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Citations

Aug 8, 2015·International Journal of Molecular Sciences·Sebastian StevenAndreas Daiber
Feb 3, 2016·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Jörn F DopheideChristine Espinola-Klein
May 15, 2015·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·K A VolaklisB Thorand
Feb 6, 2018·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Sara RadenovicHans-Dirk Düngen
Apr 4, 2018·Physiological Reports·Panagiotis KoutakisWilliam T Bohannon
Jun 25, 2020·International Journal of Molecular Sciences·Salvatore Santo SignorelliDomenico Di Raimondo

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