PMID: 15374374Sep 1, 1992Paper

Change with donor age in the degradation rate of endogenous proteins of mouse hepatocytes in primary culture

Archives of Gerontology and Geriatrics
T IkedaS Goto

Abstract

The degradation rate of [(3)H]leucine labeled intracellular proteins was compared in hepatocytes derived from young (4-7-month-old) and aged (23-month-old) mice. Average half-lives of long-lived proteins were 40 h and 65 h in the cells from young and old animals, respectively. This observation confirms our earlier results that half-lives of foreign proteins introduced into the cells from old mice are 50-60% longer than those of younger counterparts (Ishigami and Goto, 1988, Mech. Ageing Dev., 46, 125-133; Ishigami and Goto, 1990, Arch. Biochem. Biophys., 277, 189-195).

References

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Citations

May 1, 1993·Archives of Gerontology and Geriatrics·S MorimotoS Goto
Sep 1, 1994·Archives of Gerontology and Geriatrics·S Goto
Sep 9, 2000·Experimental Gerontology·A J Lambert, B J Merry
Nov 9, 2002·Microscopy Research and Technique·Ryoya Takahashi, Sataro Goto
Mar 3, 2009·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Karen MathijsJoost H M van Delft
Jan 25, 2002·Annals of the New York Academy of Sciences·S GotoR Abe

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