Changed frontal pole gene expression suggest altered interplay between neurotransmitter, developmental, and inflammatory pathways in schizophrenia

NPJ Schizophrenia
Elizabeth ScarrBrian Dean

Abstract

Schizophrenia (Sz) probably occurs after genetically susceptible individuals encounter a deleterious environmental factor that triggers epigenetic mechanisms to change CNS gene expression. To determine if omnibus changes in CNS gene expression are present in Sz, we compared mRNA levels in the frontal pole (Brodmann's area (BA) 10), the dorsolateral prefrontal cortex (BA 9) and cingulate cortex (BA 33) from 15 subjects with Sz and 15 controls using the Affymetrix™ Human Exon 1.0 ST Array. Differences in mRNA levels (±≥20%; p < 0.01) were identified (JMP Genomics 5.1) and used to predict pathways and gene x gene interactions that would be affected by the changes in gene expression using Ingenuity Pathway Analysis. There was significant variation in mRNA levels with diagnoses for 566 genes in BA 10, 65 genes in BA 9 and 40 genes in BA 33. In Sz, there was an over-representation of genes with changed expression involved in inflammation and development in BA 10, cell morphology in BA 9 and amino acid metabolism and small molecule biochemistry in BA 33. Using 94 genes with altered levels of expression in BA 10 from subjects with Sz, it was possible to construct an interactome of proven direct gene x gene interactions that was enriche...Continue Reading

References

Feb 1, 1995·Brain Research. Molecular Brain Research·A E KingsburyC D Marsden
Apr 1, 1996·The American Journal of Psychiatry·C HillD Copolov
May 2, 1998·The Australian and New Zealand Journal of Psychiatry·S B RobertsD L Copolov
Feb 22, 2000·Biological Psychiatry·M Tsuang
Sep 28, 2000·Trends in Neurosciences·J Duncan, A M Owen
Apr 11, 2001·Proceedings of the National Academy of Sciences of the United States of America·Y HakakA A Fienberg
Jul 2, 2002·Archives of General Psychiatry·Scott E HembyJames H Eberwine
Oct 5, 2002·Schizophrenia Research·Marquis P VawterWilliam J Freed
Nov 20, 2002·Journal of Neurochemistry·Outi KontkanenEero Castrén
Dec 10, 2003·Archives of General Psychiatry·Patrick F SullivanMichael C Neale
Nov 16, 2004·Annals of the New York Academy of Sciences·Tetsuji SugaiHiroyuki Nawa
May 24, 2005·Progress in Neuro-psychopharmacology & Biological Psychiatry·L Fredrik JarskogJeffrey A Lieberman
May 27, 2005·PLoS Medicine·Sukanta SahaJohn McGrath
Jun 9, 2005·Neurochemistry International·Liliána Z FehérAndrás Palotás
Sep 1, 2005·European Archives of Psychiatry and Clinical Neuroscience·Juan Carlos Sanz de la TorreCarme Junqué
Oct 15, 2005·Proceedings of the National Academy of Sciences of the United States of America·Stephen J GlattMing T Tsuang
Jan 13, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·S Hossein FatemiMitsunori Fukuda
Sep 26, 2006·Biological Psychiatry·Barbara K LipskaJoel E Kleinman
Oct 19, 2006·Brain Research·Ana D StanCarol A Tamminga
Apr 28, 2007·The Australian and New Zealand Journal of Psychiatry·Brian DeanElizabeth A Thomas
Oct 27, 2007·Science·Etienne Koechlin, Alexandre Hyafil
May 1, 2008·BMC Genomics·Nikola A BowdenPaul A Tooney
Aug 7, 2008·Journal of Neuroscience Research·Sujatha NarayanElizabeth A Thomas
Sep 10, 2008·Brain Research·Sujatha NarayanElizabeth A Thomas
Jun 26, 2009·Current Opinion in Psychiatry·Brian DeanElizabeth Scarr
Nov 12, 2009·Future Oncology·Ahmed H MekkawyMohammad H Pourgholami
Sep 4, 2010·Journal of Developmental and Behavioral Pediatrics : JDBP·Daniel Z Wetmore, Craig C Garner
Oct 5, 2010·Biological Psychiatry·Jane A EnglishDavid R Cotter
Mar 11, 2011·Trends in Cognitive Sciences·Satoshi TsujimotoSteven P Wise
Apr 7, 2012·Trends in Genetics : TIG·Vijay K RamananAndrew J Saykin

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Citations

Jun 30, 2018·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Srisaiyini KidnapillaiKen Walder
Dec 5, 2018·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Brian DeanJames A Duce
Feb 23, 2020·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Andrew S GibbonsBrian Dean
Jan 11, 2020·Frontiers in Psychiatry·Ashutosh KumarPavan Kumar
Dec 20, 2020·Psychiatry Research. Neuroimaging·Vikas B RajuNaren P Rao
Apr 22, 2020·Psychiatry Research·Brian Dean, Elizabeth Scarr

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Methods Mentioned

BETA
PCR
chips
chip

Software Mentioned

IPA Pathway Explorer
IPA Ready Genes
JMP Genomics
IPA
Pathway Explorer

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