Changes across time in the temporal responses of auditory nerve fibers stimulated by electric pulse trains.

Journal of the Association for Research in Otolaryngology : JARO
Charles A MillerP J Abbas

Abstract

Most auditory prostheses use modulated electric pulse trains to excite the auditory nerve. There are, however, scant data regarding the effects of pulse trains on auditory nerve fiber (ANF) responses across the duration of such stimuli. We examined how temporal ANF properties changed with level and pulse rate across 300-ms pulse trains. Four measures were examined: (1) first-spike latency, (2) interspike interval (ISI), (3) vector strength (VS), and (4) Fano factor (FF, an index of the temporal variability of responsiveness). Data were obtained using 250-, 1,000-, and 5,000-pulse/s stimuli. First-spike latency decreased with increasing spike rate, with relatively small decrements observed for 5,000-pulse/s trains, presumably reflecting integration. ISIs to low-rate (250 pulse/s) trains were strongly locked to the stimuli, whereas ISIs evoked with 5,000-pulse/s trains were dominated by refractory and adaptation effects. Across time, VS decreased for low-rate trains but not for 5,000-pulse/s stimuli. At relatively high spike rates (>200 spike/s), VS values for 5,000-pulse/s trains were lower than those obtained with 250-pulse/s stimuli (even after accounting for the smaller periods of the 5,000-pulse/s stimuli), indicating a desy...Continue Reading

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Citations

Mar 25, 2009·Journal of the Association for Research in Otolaryngology : JARO·David E O'GormanChristopher A Shera
Dec 25, 2009·Journal of the Association for Research in Otolaryngology : JARO·Jihwan WooPaul J Abbas
Jul 16, 2010·Journal of the Association for Research in Otolaryngology : JARO·Ning HuJihwan Woo
Nov 17, 2010·Journal of the Association for Research in Otolaryngology : JARO·Charles A MillerBarbara K Robinson
May 10, 2012·Journal of the Association for Research in Otolaryngology : JARO·Michael Hofmann, Jan Wouters
Jun 8, 2012·Journal of Neurophysiology·Joshua H GoldwynEric Shea-Brown
May 19, 2009·Trends in Amplification·Christina L Runge-Samuelson
Nov 30, 2010·The Journal of the Acoustical Society of America·David E O'GormanChristopher A Shera
Feb 14, 2012·Hearing Research·Michelle L HughesJacquelyn L Baudhuin
Sep 11, 2010·The Laryngoscope·Philip D LittlefieldClaus-Peter Richter
Jun 4, 2014·IEEE Transactions on Bio-medical Engineering·Mohamed H Negm, Ian C Bruce
May 29, 2009·IEEE Transactions on Bio-medical Engineering·Jihwan WooPaul J Abbas
Jun 6, 2009·IEEE Transactions on Bio-medical Engineering·Jihwan WooPaul J Abbas
Mar 11, 2015·Computational and Mathematical Methods in Medicine·Soojin KangJihwan Woo
Aug 31, 2016·Network : Computation in Neural Systems·Mathias Dietz
Aug 31, 2016·Network : Computation in Neural Systems·Marko TakanenBernhard U Seeber
Apr 14, 2016·Network : Computation in Neural Systems·Gabrielle E O'Brien, Jay T Rubinstein
Nov 17, 2015·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Dietmar BastaArne Ernst
Feb 23, 2017·Journal of the Association for Research in Otolaryngology : JARO·Youssef AdelOlivier Macherey
May 3, 2018·Nature Communications·Thomas MagerErnst Bamberg
Mar 16, 2012·Journal of Neural Engineering·Luke J CampbellStephen John O'Leary
Mar 14, 2018·Journal of the Association for Research in Otolaryngology : JARO·Mahan AzadpourMario A Svirsky
Jan 6, 2017·Journal of the Association for Research in Otolaryngology : JARO·Suyash Narendra JoshiBastian Epp
Dec 13, 2016·Journal of the Association for Research in Otolaryngology : JARO·Jason Boulet, Ian C Bruce
Jul 12, 2017·Frontiers in Neuroscience·Shuman HeCraig A Buchman
Feb 9, 2020·Hearing Research·Sonia TabibiNorbert Dillier
Oct 27, 2020·International Archives of Otorhinolaryngology·Bettina CarvalhoRogerio Hamerschmidt
Mar 25, 2021·Brain Stimulation·Clemens NeudorferAndres M Lozano
Apr 24, 2021·Journal of the Association for Research in Otolaryngology : JARO·Yaqing SuBertrand Delgutte
May 7, 2021·Journal of Neuroscience Methods·Sonia TabibiIan C Bruce

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