Changes in 18F-FDG uptake within minutes after chemotherapy in a rabbit VX2 tumor model

Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
Shao-Li SongTao Chen

Abstract

The purpose of this study was to investigate whether (18)F-FDG PET/CT can be used for in vivo chemosensitivity testing and to determine the optimal time point for observation. Forty-two rabbits with 84 implanted VX2 squamous cell tumors were randomized into a control group (n = 10) and a treatment group (n = 32). (18)F-FDG PET/CT was performed the day before intravenous administration of cisplatin (4 mg/kg) and at 95-100 min (day 0), day 1, day 7, and day 14 afterward. In the control group, (18)F-FDG PET/CT images were acquired at the same time points but without cisplatin administration. Maximum standardized uptake value (SUV) and mean SUV were analyzed. On the basis of tumor volume, we categorized animal tumors into a sensitive group and an insensitive group. If tumor volume doubled by day 7, the tumor was considered insensitive. On day 0, maximum SUV and mean SUV were significantly different between the sensitive group and the insensitive and control groups (P < 0.05 for both). In the sensitive group, the average change from the pretherapy values was -48.96% +/- 12.27% for maximum SUV and -51.63% +/- 10.45% for mean SUV. SUV did not significantly differ between the groups at any other points (days 1-14). On day 0, tumor volu...Continue Reading

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Citations

Jan 29, 2010·European Journal of Nuclear Medicine and Molecular Imaging·Nicolas AideRodney J Hicks
Sep 1, 2011·Annals of Nuclear Medicine·Jun Toyohara, Kiichi Ishiwata
Sep 16, 2011·Cancer Informatics·Hideyuki NishiofukuKimihiko Kichikawa
Jan 17, 2012·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·Yu ping XuGuoqiang Shao
Apr 19, 2011·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Shaoli SongChun Li

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