PMID: 15997191Jul 6, 2005Paper

Changes in activities of enzymes related to energy metabolism in canine lymphoma cells

The Journal of Veterinary Medical Science
Tsukimi WashizuToshiro Arai

Abstract

Alterations in the activities of enzymes related to energy metabolism in canine lymphoma cells were investigated. Cytosolic pyruvate kinase (PK) and mitochondrial malate dehydrogenase (MDH) activities in lymphoma cells were significantly higher than those in lymphocytes obtained from lymph nodes of healthy dogs, whereas cytosolic lactate dehydrogenase (LDH) activity was significantly lower in lymphoma cells. The cytosolic M/L ratio (MDH activity/LDH activity), which is considered to be a good indicator of energy metabolism related to glucose utilization in animal tissues, was significantly higher in lymphoma cells than in the normal lymphocytes.

References

Aug 1, 1990·Cancer·P G GreenleeP H Lieberman
Jan 1, 1990·Journal of Veterinary Internal Medicine·David M VailR L Hegstad
Apr 1, 1981·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·N DeshpandeR Millis
Jan 1, 1994·Journal of Veterinary Internal Medicine·G K OgilvieM J Fettman
Dec 6, 2002·Journal of Veterinary Internal Medicine·Laura D GarrettDavid M Vail
Dec 25, 2002·The Journal of Veterinary Medical Science·Toshiro AraiYasuyuki Ohnishi
Apr 1, 1956·Proceedings of the Society for Experimental Biology and Medicine·A SIEGEL, R J BING
Feb 21, 2004·The Veterinary Journal·Frédérique PonceCorinne Fournel-Fleury

Related Concepts

SGOT - Glutamate oxaloacetate transaminase
Cytoplasmic Matrix
Dog Diseases
Canis familiaris
Energy Metabolism
Hexokinase 2
Lactate Dehydrogenase
Lymphoid Cells
Lymphoma
Malate Dehydrogenase

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