Changes in activities of some ammonia-metabolizing enzymes in the rat liver and the brain after chronic ethanol administration

Biochemical Medicine and Metabolic Biology
R FarbiszewskiM Chwiecko

Abstract

The changes in the activities of ammonia-metabolizing enzymes in liver and brain after ethanol intoxication has been investigated in rats. After administration of ethanol 30% (w/v) 6g kg-1 for 4 weeks we found an increase in liver glutamate dehydrogenase and glutaminase activity. In brain tissue the glutaminase activity was significantly higher and glutamate dehydrogenase was significantly lower. Glutamine synthetase activity in liver and brain was practically unchanged. The reasons for these changes in the activities of some ammonia-metabolizing enzymes in liver and brain after ethanol ingestion have been discussed.

References

Mar 25, 1977·Science·A Martinez-HernandezM D Norenberg
Feb 2, 1979·Brain Research·M D Norenberg, A Martinez-Hernandez
Mar 9, 1987·Neuroscience Letters·L C WardS Mason
Oct 1, 1986·Biochemical Medicine and Metabolic Biology·R FarbiszewskiA Sokol
Nov 1, 1966·The Analyst·A S CurryG S Simpson
Jan 1, 1983·Pharmacology, Biochemistry, and Behavior·M J CoonE T Morgan
Dec 1, 1958·The Journal of Clinical Investigation·K S WARREN, D G NATHAN

Citations

Nov 20, 2012·Psychosomatics·Elie Isenberg-GrzedaStephen E Nicolson

Related Concepts

Ethanol
Ammonia
Desire for Food
Brain
Glutamate Dehydrogenase
Phosphate-Activated Glutaminase
Glutamate-Ammonia Ligase
Liver
August Rats

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