Changes in acute-phase proteins during lithium potentiation of antidepressants in refractory depression

Neuropsychobiology
A SluzewskaJ Rybakowski

Abstract

This study was performed on 32 patients with refractory depression in whom lithium was added to antidepressant treatment in order to potentiate the therapeutic effect, and in 20 healthy controls. Plasma concentration of three acute-phase proteins (APPs): C-reactive protein, alpha-1-acid glycoprotein (AGP) and alpha-1-antichymotrypsin (ACT) as well as microheterogeneity of AGP and ACT were measured, before and after 4 weeks of lithium addition to antidepressants. Before Li addition, all patients studied had elevated values of APPs, which suggested the existence of immunological activation. A significant decrease in plasma levels of all APPs and the decrease of glycosylation values of AGP and ACT was observed after Li potentiation. A favorable clinical effect of lithium potentiation after 4 weeks was found in 24 patients (75%). Nonresponders to Li potentiation differed from responsers by their immunological indices prior to Li addition. They had higher values of reactivity coefficients, which means more inflammatory patterns.

Citations

Oct 31, 2002·Human Psychopharmacology·Michael Maes
Apr 27, 2007·Der Nervenarzt·T BschorM Bauer
Oct 19, 2004·Journal of Affective Disorders·Fotini BoufidouGeorge N Christodoulou
Aug 22, 2001·Biological Psychiatry·M H Rapaport, H K Manji
Jul 15, 1999·Journal of Psychiatric Research·M H RapaportP Whybrow
Mar 14, 2001·Journal of Affective Disorders·M RothermundtH Kirchner
May 9, 1998·Journal of Affective Disorders·M HornigJ D Amsterdam
Oct 8, 1999·Journal of Affective Disorders·M HornigD B Goodman
Nov 28, 2002·Progress in Neuro-psychopharmacology & Biological Psychiatry·Francesco BenedettiEnrico Smeraldi
Sep 16, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Ebrahim HaroonAndrew H Miller
Sep 20, 2012·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Annamaria CattaneoCarmine M Pariante
Jun 7, 2011·Reviews in the Neurosciences·Christopher F Sharpley, Linda L Agnew
Jul 19, 2014·Biogerontology·Aurel Popa-WagnerCarmen Valeria Albu
Feb 26, 2008·European Archives of Psychiatry and Clinical Neuroscience·Angelo B CunhaFlávio Kapczinski
Aug 9, 2002·Journal of Affective Disorders·Kuan-Pin SuShang-Ying M Tsai
Aug 21, 2013·Current Psychiatry Reports·Nora HamdaniMarion Leboyer
Sep 6, 2012·Neuropsychobiology·Agnieszka Remlinger-MolendaJanusz K Rybakowski
Apr 11, 2014·International Review of Psychiatry·Jorge Luis SoteloCharles Nemeroff
Oct 9, 2012·Expert Review of Neurotherapeutics·Robert K McNamara, Francis E Lotrich
Aug 10, 2001·Drug Metabolism Reviews·Z H Israili, P G Dayton
Mar 18, 2011·Psychoneuroendocrinology·Milena GirottiDavid A Morilak
Feb 22, 2011·Pharmacology & Therapeutics·Lucile Capuron, Andrew H Miller
Jul 6, 2010·Progress in Neuro-psychopharmacology & Biological Psychiatry·Michael Maes
Nov 26, 2015·Psychiatry Research·Kathleen Watson LinNatalie L Rasgon
Oct 13, 2009·Brain, Behavior, and Immunity·Andrew H Miller
Apr 17, 2007·Journal of Affective Disorders·Yong-Ku KimSun-Hwa Park
Jul 3, 2015·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Catherine Toben, Bernhard T Baune
Sep 13, 2013·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Natalie T MillsBernhard T Baune
Jan 20, 2009·Biological Psychiatry·Andrew H MillerCharles L Raison
Nov 26, 2015·Neural Regeneration Research·Raluca Elena SanduAurel Popa-Wagner
Dec 1, 2005·Trends in Immunology·Charles L RaisonAndrew H Miller
Jan 31, 2006·The American Journal of Medicine·Irving KushnerDavid Samols
Aug 6, 2014·European Journal of Pharmacology·Olivia F O'LearyJohn F Cryan
Jul 28, 2011·Progress in Neuro-psychopharmacology & Biological Psychiatry·Ying WangWen Jiang
Sep 22, 2001·Brain, Behavior, and Immunity·E P ZorrillaK Schmidt

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.