Abstract
To explore the changes in amplitude-integrated electroencephalography (aEEG), neuron-specific enolase (NSE), and S100B in neonates with brain injury induced by neonatal hyperbilirubinemia (NHB). 67 neonates with brain injury induced by NHB admitted to our hospital from March 2016 to October 2018 were included in a brain injury group (BIG), and 82 neonates with NHB but without brain injury in our hospital during the same period were included in a non-BIG. The two groups were compared regarding the rates of normal and abnormal aEEG results. The proportion of normal aEEG results in the BIG was significantly lower than that in the non-BIG, and the proportion of moderately and severely abnormal aEEG results in the BIG were both significantly higher than those in the non-BIG. The BIG showed significantly higher NSE and S100B levels than those of the non-BIG. The ROC curve for predicting prognosis showed that the AUC of aEEG, NSE, S100B, and the combined detection are 0.780, 0.754, 0.743, 0.788. The AUC > 0.700 indicated a good predictive value for the prognosis. The combination of aEEG, NSE, and S100B has good value in diagnosing injury induced by NHB and can predict prognosis moderately well.
References
Aug 1, 1982·Journal of Neurochemistry·R Semba, K Kato
May 29, 2010·Cardiovascular Psychiatry and Neurology·Daniela SerbinekChristian Humpel
Jan 4, 2013·Neurochemical Research·Ana Sofia FalcãoDora Brites
Nov 30, 2014·Seminars in Fetal & Neonatal Medicine·Ichiro MoriokaHajime Nakamura
Jan 7, 2015·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Ulrich GeisenClaudia Heilmann
Jan 13, 2015·Seminars in Fetal & Neonatal Medicine·Vinod K Bhutani, Lois Johnson-Hamerman
Oct 21, 2015·Molecular Pharmacology·Andreia BarateiroDora Brites
Oct 30, 2015·Journal of Pineal Research·Asilay PazarEren Ozek
Nov 2, 2016·PloS One·Ruth Del RíoAlfredo García-Alix
Aug 2, 2017·Early Human Development·Mehreen ZaighamPer Olofsson
Nov 22, 2017·Brain Injury : [BI]·Eric MercierNatalie Le Sage
Dec 14, 2017·European Journal of Clinical Nutrition·Denise C C SantosBetsy Lozoff
Jun 14, 2018·BMC Pediatrics·L ThielemansV I Carrara
Jun 14, 2018·Journal of Child Neurology·Luiza V S MagalhãesRita C Silveira
Jun 20, 2018·Turkish Journal of Medical Sciences·Esra Fırat OğuzSevilay Sezer
Aug 11, 2018·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Shujuan Chen, Robert H Tukey
Nov 24, 2018·Brain and Behavior·Piotr CzuprynaAnna Moniuszko-Malinowska
Feb 26, 2019·International Journal of Pediatrics & Adolescent Medicine·Asit Kumar Mishra, C Sanyasi Naidu
Jun 14, 2019·EClinicalMedicine·Chiara GrecoUNKNOWN study team
Aug 27, 2019·Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery·H B Shi, C Y Li
Oct 7, 2019·Neonatology·Yukihiro KitaiHiroshi Arai
Oct 11, 2019·Journal of Neurotrauma·Justus BaeckerAndrea Kleindienst