Changes in antioxidative mechanisms in elderly patients with non-insulin-dependent diabetes mellitus. Investigation of the redox dynamics of alpha-tocopherol in erythrocyte membranes

Gerontology
K YanagawaM Takasaki

Abstract

Recently, it has been suggested that the onset and aggravation of diabetes are closely related to free radicals. Also, vitamin E is a lipophilic free radical scavenger that is localized mainly in biomembranes. The purpose of this study was to clarify the defensive mechanisms against oxidative stress by investigating the differences in the redox dynamics of alpha-tocopherol in plasma and erythrocyte membranes between elderly patients with non-insulin-dependent diabetes mellitus (NIDDM) and healthy elderly subjects. Total, alpha-, beta-, gamma- and delta-tocopherol and alpha-tocopherolquinone concentrations were determined by high-performance liquid chromatography with a redox detection mode using a series of four coulometric working electrodes. The alpha-tocopherolquinone/alpha-tocopherol ratio in plasma and erythrocyte membranes was not different between the two groups. Both the alpha-tocopherol concentrations in erythrocyte membranes and ratio of alpha-tocopherol in erythrocyte membranes to alpha- tocopherol in plasma was significantly lower in elderly NIDDM patients than in healthy subjects. These findings suggest that alpha-tocopherol is used normally in both plasma and erythrocyte membranes and alpha-tocopherol uptake in er...Continue Reading

Citations

Dec 14, 2004·Journal of the American Society for Mass Spectrometry·Paul H GamacheIan N Acworth
Sep 26, 2008·Diabetes Research and Clinical Practice·Naruemon LeelayuwatVeerapol Kukongviriyapan
May 8, 2007·Mitochondrion·Plácido NavasRafael de Cabo
May 16, 2006·Ageing Research Reviews·Dong-Hoon HyunRafael de Cabo
Dec 12, 2001·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·M E BüyükokuroğluO I Küfrevioğlu
Mar 29, 2019·Archives of Pharmacal Research·Dong-Hoon Hyun
Feb 17, 2017·Interventional Medicine & Applied Science·Muobarak J Tuorkey

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