Changes in antitoxic defense systems of the freshwater amphipod Gammarus pulex exposed to BDE-47 and BDE-99

Ecotoxicology
Sibylle HorionE Gismondi

Abstract

Polybrominated diphenyl ethers (PBDEs) are emerging pollutants widely distributed in aquatic environment. Although the bioaccumulation of this compound has been well studied, few studies have investigated their impacts on antitoxic systems of invertebrates, considering both genders. Here, we have evaluated the effects of BDE-47 and BDE-99 congeners on the antitoxic defence systems of the freshwater amphipod Gammarus pulex, and especially on the multixenobiotic resistance (MXR) activity, as well as the activities of two antitoxic enzymes, the glutathione-S-transferase (GST) and the glutathione peroxidases (GPx). Results revealed that BDE-47 and BDE-99 have inhibited the MXR activity whatever the gammarid gender, which could lead to a reduction of the pollutant elimination from the organism. In addition, a gender-biased response and a congener-biased effect on the antitoxic enzymes activities were observed. Indeed, both BDE congener exposures increased the GST activity in males, whereas in females, only BDE-99 congener modified this activity by decreasing it. On the contrary, BDE exposures did not impact the GPx activity in females, while in males BDE-99 has increased it. Results of the present study highlight that a PBDE exposur...Continue Reading

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Citations

Nov 11, 2015·Environmental Pollution·Jennifer AndreïFrançois Guérold
Oct 18, 2016·Ecotoxicology and Environmental Safety·Susana BarrosTeresa Neuparth
May 28, 2019·Environmental Science and Pollution Research International·Madson Silveira de MeloEric Gismondi
Oct 2, 2020·Environmental Science and Pollution Research International·Madson Silveira de MeloEric Gismondi
Dec 29, 2020·Marine Pollution Bulletin·Eric GismondiKrishna Das
Sep 1, 2020·Ecotoxicology and Environmental Safety·Dung Thi DongDayanthi Nugegoda
Dec 22, 2019·Ecotoxicology and Environmental Safety·Madson Silveira de MeloEric Gismondi

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