Changes in arterial pressure hemodynamics in response to renal nerve stimulation both before and after renal denervation

Clinical Research in Cardiology : Official Journal of the German Cardiac Society
Annemiek F HoogerwaardArif Elvan

Abstract

Renal nerve denervation (RDN) is developed as a potential treatment for hypertension. Recently, we reported the use of renal nerve stimulation (RNS) to localize sympathetic nerve tissue for subsequent selective RDN. The effects of RNS on arterial pressure dynamics remain unknown. The current study aimed to describe the acute changes in arterial pressure dynamics response to RNS before and after RDN. Twenty six patients with drug-resistant hypertension referred for RDN were included. RNS was performed under general anesthesia before and after RDN. We continuously monitored heart rate (HR) and invasive femoral blood pressure (BP). Augmentation pressure (AP) and index (Aix), pulse pressure (PP), time to reflected wave, maximum systolic BP and dicrotic notch were calculated. Systolic and diastolic BP at site of maximum response significantly increased in response to RNS (120 ± 16/62 ± 9 to 150 ± 22/75 ± 15 mmHg) (p < 0.001/< 0.001), whereas after RDN no RNS-induced BP change was observed (p > 0.10). RNS increased Aix (29 ± 11 to 32 ± 13%, p = 0.005), PP (59 ± 14 to 75 ± 17 mmHg, p < 0.001), time to reflected wave (63 ± 18 to 71 ± 25 ms, p = 0.004) and time to maximum systolic pressure (167 ± 36 to 181 ± 46 ms, p = 0.004) before RDN...Continue Reading

References

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Citations

Jul 5, 2018·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Lucas LauderFelix Mahfoud
Apr 8, 2019·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Mark LipphardtManuel Wallbach
Aug 8, 2019·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Manuel WallbachMichael J Koziolek
Nov 3, 2020·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Lucas LauderFelix Mahfoud
Apr 2, 2021·Circulation Research·Felix MahfoudMelvin D Lobo
Oct 15, 2021·Blood Pressure·Annemiek F HoogerwaardArif Elvan

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