Apr 2, 2003

Changes in articular cartilage and subchondral bone histomorphometry in osteoarthritic knee joints in humans

Bone
Dragica BobinacIvana Maric

Abstract

In this study, we have examined the correlation between the histological and histochemical changes of articular cartilage and bone parameters of the underlying subchondral bone. The aim was to elucidate patterns of bone parameter changes within different depths of subchondral bone in the joints with macroscopically normal cartilage and in joints with osteoarthritis (OA). Ten tibial plateaus were taken from patients during total knee replacement surgery due to severe OA. They were compared with 10 sets of tibial condyles obtained from autopsy subjects with no history of bone or joint disease. The cylindrical cartilage-bone samples were taken out from the anterior, posterior, external, and internal areas of the condyles for cartilage assessment (Mankin score) and subchondral bone histomorphometry. Four histomorphometric parameters were measured: bone volume (BV/TV), trabecular thickness (Tb.Th), trabecular number (Tb.N), and trabecular separation (Tb.S). Our study showed that subchondral bone from the OA group had significantly higher bone volume (54.1 +/- 10.6%) than control group (37.8 +/- 8.1%) (P < 0.01). In addition, trabecular parameters from the OA subchondral bone showed a smaller number of sparsely distributed and thicke...Continue Reading

  • References10
  • Citations151

Citations

Mentioned in this Paper

Phenazines
Degenerative Polyarthritis
Articular System
Autopsy
Structure of Articular Cartilage
Structure of Condyle
Joints
Entire Articular Cartilage
Knee Joint
Osteoarthritis, Knee

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