Changes in atrial natriuretic peptide levels during cardiac bypass in the fetal goat

Artificial Organs
Chengbin ZhouJinfang Zhang

Abstract

The aim of this study is to evaluate the effect of fetal cardiac bypass on the production and secretion of fetal atrial natriuretic peptide (ANP) in the goat. Eighteen pregnant goats, at days 120 to 140 of gestation, were randomly divided into control (n = 8) and bypass (n = 10) groups. The control group underwent a sham procedure involving fetal sternotomy and cannulation. The bypass group underwent fetal cardiac bypass using a centrifugal pump for 30 min. Fetuses in the bypass group exhibited hypoxia, hypercapnia, and acidosis during and after cardiac bypass. The pulse index (PI) of the umbilical artery in the bypass group increased significantly after cardiac bypass compared with the control group. Tei indices of the left and right ventricles in the bypass group increased remarkably after cardiac bypass. Plasma troponin I levels in the bypass group increased significantly compared with that of the control group. Plasma ANP levels increased markedly in the bypass group after cardiac bypass, and the difference between two groups was significant. Transcriptional levels of ANP mRNA in the fetal heart elevated remarkably in the bypass group compared with the control group at 2 h after the bypass. A significant positive correlatio...Continue Reading

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Citations

Feb 28, 2009·Artificial Organs·Paul S Malchesky
Aug 9, 2011·The Journal of Thoracic and Cardiovascular Surgery·Cheng-Bin ZhouRaphael C Lui
Oct 5, 2010·The Journal of Thoracic and Cardiovascular Surgery·Jodie Y DuffyPirooz Eghtesady
Sep 28, 2010·The Annals of Thoracic Surgery·Orlando PetrucciPirooz Eghtesady
Jul 16, 2013·Biochimica Et Biophysica Acta·Irina A Sergeeva, Vincent M Christoffels
Mar 17, 2010·Circulation·Doff B McElhinneyJames E Lock
Oct 1, 2017·Experimental and Therapeutic Medicine·Fei XiaoShu-Sheng Wen

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