PMID: 9547123Apr 18, 1998Paper

Changes in auditory P300 in patients with major depression and silent cerebral infarction

Journal of Affective Disorders
I YanaiY Touhouda

Abstract

We examined event-related potentials in patients with senile depression and silent cerebral infarction (SCI) to clarify the features of the P300 component. P300 event-related potentials were recorded in drug-free depressed patients (N = 16) and normal controls (N = 17). All patients underwent magnetic resonance imaging and were classified as SCI-positive (N = 7) or SCI-negative (N = 9). In depressed patients, the P300 was reexamined after antidepressant treatment. Prior to treatment, P300 amplitudes in depressed patients were significantly smaller than those in normal controls (P < 0.01). P300 amplitudes increased significantly in SCI-negative patients following recovery (P < 0.05), but did not change in SCI-positive patients. SCI may interrupt the treatment-related P300 amplitude increase in depressed patients.

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Citations

Sep 27, 2003·Psychiatry Research·Rebecca J HoustonVictor M Hesselbrock
Feb 1, 2002·Acta Neuropsychiatrica·E F P M VuurmanJ Jolles
Jun 15, 2014·Neuroscience Letters·Kyung Mook ChoiJeong-Ho Chae
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