Changes in BAER wave amplitudes in relation to total serum bilirubin level in term neonates.

European Journal of Pediatrics
Ze Dong JiangAndrew R Wilkinson

Abstract

Whether the severity of bilirubin neurotoxicity is closely related to the level of total serum bilirubin (TSB) remains to be determined. We studied the amplitudes of brainstem auditory evoked response (BAER) components in 83 term neonates with TSB >10 mg/dL to detect any differences in bilirubin ototoxic effect on the amplitudes between different levels of TSB. Compared to age-matched normal controls, the amplitudes of BAER waves III and V were reduced significantly (P<0.01 and 0.001). The V/I and V/III amplitude ratios were also decreased significantly (P<0.001 and 0.01). Although all amplitudes tended to be lower at higher TSB levels than at lower levels, none of the amplitudes correlated significantly with the level of TSB. Neither the V/I amplitude ratio nor the V/III amplitude ratio correlated with the TSB. No significant differences were found in any BAER wave amplitudes among the TSB levels 11-15, 16-20 and >20 mg/dL. In the comparison of amplitude data between any two of the three TSB levels, only wave V amplitude showed significant difference between TSB levels 11-15 and >20 mg/dL (P < 0.05). BAER wave amplitudes were significantly reduced in neonates with hyperbilirubinemia. However, there was no close correlation bet...Continue Reading

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Citations

Dec 7, 2013·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·Ze D JiangCao Chen
Oct 8, 2013·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Rasool PanahiSara Hasani
May 29, 2016·Clinics in Perinatology·Cristen Olds, John S Oghalai
Jan 5, 2016·Brazilian Journal of Otorhinolaryngology·Çağıl GökdoğanLeyla Memiş
May 7, 2013·International Journal of Pediatric Otorhinolaryngology·Olubunmi Victoria AkinpeluSam J Daniel
Jan 13, 2015·Seminars in Fetal & Neonatal Medicine·Cristen Olds, John S Oghalai
Sep 9, 2010·Journal of Child Neurology·Ze D JiangAndrew R Wilkinson

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