Changes in Bcl-2 and p53 expression in recurrent B-cell lymphomas

The Journal of Pathology
M IlyasN Rooney

Abstract

The aim of this study was to investigate the changes involved in the evolution of nine cases of recurrent B-cell lymphomas. Using the polymerase chain reaction (PCR) on formalin-fixed, paraffin-embedded tissue from both the primary and the recurrent lymphoma of each case, monoclonality was demonstrated in every tumour. In all nine cases, the recurrent lymphoma was shown to belong to the same clone as the primary lymphoma. Eight of these cases were then investigated by immunohistochemistry for changes in Bcl-2 and p53 expression. Five out of eight of the primary lymphomas showed Bcl-2 overexpression. Two of the three cases initially negative for Bcl-2 expression became positive in the recurrence. One out of eight of the primary lymphomas was positive for p53 expression. Of the seven negative cases, one became positive for p53 expression in the recurrence. Both of the p53-positive cases showed high-grade histology. This study shows that Bcl-2 overexpression is probably an important early event in the development of B-cell lymphomas, although it may occur as a post-neoplastic event. p53 mutation is probably more important as a late event and may be associated with high-grade transformation.

References

Feb 4, 1978·Lancet·M J HillH J Bussey
Dec 1, 1975·Cancer·T MutoB C Morson
Mar 1, 1992·The Journal of Pathology·R VilluendasP Martinez
Aug 1, 1992·Immunology Today·S J Korsmeyer
Jul 2, 1992·Nature·D P Lane
Jul 1, 1991·British Journal of Cancer·S M BellP Quirke
Jun 1, 1990·Cell·E R Fearon, B Vogelstein
Jun 21, 1985·Science·Y TsujimotoC M Croce
Dec 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·R Dalla-FaveraC M Croce
Jan 1, 1995·Histopathology·M Ashton-KeyD Y Mason
Dec 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·A G Knudson
Aug 1, 1994·Gastroenterology·S E KernK W Kinzler
Feb 1, 1994·British Journal of Cancer·M A PirisF ] Pezella F [corrected to Pezzella
Jul 1, 1958·Journal of Chronic Diseases·L FOULDS

❮ Previous
Next ❯

Citations

Apr 30, 1998·Genetics·B S Strauss

❮ Previous
Next ❯

Related Concepts

Related Feeds

B-Cell Lymphoma

B-cell lymphomas include lymphomas that affect B cells. This subtype of cancer accounts for over 80% of non-Hodgkin lymphomas in the US. Here is the latest research.

BCL-2 Family Proteins

BLC-2 family proteins are a group that share the same homologous BH domain. They play many different roles including pro-survival signals, mitochondria-mediated apoptosis and removal or damaged cells. They are often regulated by phosphorylation, affecting their catalytic activity. Here is the latest research on BCL-2 family proteins.