Changes in behavioural parameters, oxidative stress and neurotrophins in the brain of adult offspring induced to an animal model of schizophrenia: The effects of FA deficient or FA supplemented diet during the neurodevelopmental phase

Progress in Neuro-psychopharmacology & Biological Psychiatry
Lara CaneverAlexandra I Zugno

Abstract

A deficiency of maternal folic acid (FA) can compromise the function and development of the brain, and may produce a susceptibility to diseases such as schizophrenia (SZ) in the later life of offspring. The aim of this study was to evaluate the effects of both FA deficient and FA supplemented diets during gestation and lactation on behavioural parameters, the markers of oxidative stress and neurotrophic factors in adult offspring which had been subjected to an animal model of SZ. Female mother rats (Dam's) were separated into experimental maternal groups, which began receiving a special diet (food) consisting of the AIN-93 diet, a control diet, or an FA deficient diet during the periods of pregnancy and lactation. Dam's receiving the control diet were further subdivided into four groups: one group received only control diet, while three groups to receive supplementation with FA at different doses (5, 10 and 50 mg/kg). Adult offspring bred from the Dam's were divided into ten groups for induction of the animal model of SZ through the administration of ketamine (Ket) (25 mg/kg). After the last administration of the drug, the animals were subjected to the behavioural tests and were then euthanized. The frontal cortex (FC) and hipp...Continue Reading

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Citations

Nov 1, 2020·International Journal of Molecular Sciences·Grégory PouriéCarine Bossenmeyer-Pourié
Apr 1, 2021·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Lara CaneverAlexandra I Zugno
May 22, 2021·Behavioural Brain Research·Arthur Rocha-GomesHércules Ribeiro Leite
Jul 7, 2021·Biochemistry. Biokhimii︠a︡·Alexander V ArutjunyanIrina V Zalozniaia

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