Changes in benzodiazepine-GABA receptor coupling in an accumbens-habenula circuit after chronic diazepam treatment

British Journal of Pharmacology
R R Brett, J A Pratt

Abstract

1. The effects of subacute and of chronic diazepam treatment upon binding to the GABAA receptor have been examined by use of receptor autoradiography for determining flunitrazepam (FNZP) binding, GABA enhancement of FNZP binding. SR 95531 2-(3'-carboxy-2',propyl)-3-amino-6-p-methoxyphenylpyridazinium bromide) binding and GABA binding in parallel sections from rat brain. Prior to the autoradiographic procedures, a behavioural assessment of the rats was made in the elevated plus-maze test of anxiety. 2. Rats receiving diazepam either subacutely (3 days) or chronically (28 days) by both continuous release, from previously implanted subcutaneous silastic capsules, or by daily injection (5 mg kg-1) did not display changes in FNZP or GABA binding in any of the 47 brain structures analysed. Similarly, there were no significant effects of treatment upon mean total entries or on the open:total ratio for entries in the elevated plus-maze. 3. There were reductions in the GABA enhancement of FNZP binding in the nucleus accumbens and central grey after subacute diazepam treatment. This effect persisted in the nucleus accumbens after chronic treatment. Less marked effects occurred in the lateral habenula, dorsal raphe and substantia nigra pa...Continue Reading

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Citations

Jun 23, 2001·Pharmacology, Biochemistry, and Behavior·J M FaheyD J Greenblatt
May 20, 1998·Pharmacology, Biochemistry, and Behavior·J A PrattD J Laurie
May 3, 2003·Pharmacology & Therapeutics·C Allison, J A Pratt
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Apr 27, 2012·Advances in Pharmacological Sciences·Christiaan H Vinkers, Berend Olivier
May 6, 2020·International Journal of Molecular Sciences·Hana KubováPavel Mareš

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