Changes in Bile Acid Profile After Laparoscopic Sleeve Gastrectomy are Associated with Improvements in Metabolic Profile and Fatty Liver Disease

Obesity Surgery
Ajay P BelgaumkarAmeet G Patel

Abstract

Bile acids (BA) modulate lipid and glucose metabolism in a feedback loop through production of fibroblast growth factor (FGF) 19 in the terminal ileum. Changes in BA after bariatric surgery may lead to improvements in the metabolic syndrome, including fatty liver disease. This study investigated the relationship between BA and metabolic and inflammatory profiles after laparoscopic sleeve gastrectomy (LSG). Patients undergoing LSG had fasting blood samples taken pre-operatively and 6 months post-surgery. Liver injury was measured using cytokeratin (CK) 18 fragments. BA were measured using liquid chromatography tandem-mass spectrometry. FGF-19 was measured using enzyme-linked immunosorbent assay. The study included 18 patients (12 females), with mean age 46.3 years (SEM ± 2.9) and BMI 60.1 kg/m(2) (±2.6). After 6 months, patients lost 39.8 kg (±3.1; p < 0.001). Fourteen patients (78 %) had steatosis. FGF-19 increased from median 128.1 (IQR 89.4-210.1) to 177.1 (121.8-288.9, p = 0.045) at 6 months. Although total BA did not change, primary glycine- and taurine-conjugated BA, cholic acid decreased, and secondary BA, glycine-conjugated urodeoxycholic acid increased over the study period. These changes are associated with reduction i...Continue Reading

References

May 27, 2004·Diabetes Care·Tara M WallaceDavid R Matthews
Jun 27, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Anna WieckowskaAriel E Feldstein
May 10, 2008·European Journal of Gastroenterology & Hepatology·Márcia M AranhaCecília M P Rodrigues
Sep 9, 2008·Endocrinology and Metabolism Clinics of North America·Guenther Boden
Nov 11, 2008·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Dima L DiabAriel E Feldstein
Jul 9, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Ariel E FeldsteinArthur J McCullough
Feb 15, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Elizabeth M BruntUNKNOWN NASH Clinical Research Network (CRN)
Jan 1, 2010·Nuclear Receptor Signaling·Salvatore ModicaAntonio Moschetta
Jun 18, 2011·Current Opinion in Clinical Nutrition and Metabolic Care·Eduardo EsteveJose-Manuel Fernández-Real
Jun 30, 2011·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Vyacheslav U BukoHorst-Dietmar Tauschel
Dec 21, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Anita PathilWolfgang Stremmel
May 17, 2012·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·S Raghavendra Rao
Jul 28, 2012·Annals of Medicine·Nassim Dali-YoucefEmmanuel Andrès
Nov 20, 2012·Annals of Surgery·John MelissasNikolaos Karkavitsas
Jan 10, 2013·Current Opinion in Lipidology·X Julia XuNeil B Ruderman
Jan 10, 2013·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Lars P BechmannAli Canbay
Jan 26, 2013·Clinics and Research in Hepatology and Gastroenterology·Albert Tran, Philippe Gual
May 1, 2013·Clinical Science·Alisan KahramanAli Canbay
May 3, 2013·BMJ : British Medical Journal·Amanda Owen-SmithJoanna Coast
Jun 26, 2013·Endocrinology·D J Pournaras, C W le Roux
Aug 31, 2013·Biochemical Pharmacology·Yuanyuan LiYanqiao Zhang
Sep 21, 2013·Scandinavian Journal of Gastroenterology·Malin WerlingCarel W Le Roux
Oct 3, 2013·Toxicological Sciences : an Official Journal of the Society of Toxicology·Lina LuoJennifer L Colangelo
Mar 29, 2014·Nature·Karen K RyanRandy J Seeley
Feb 25, 2015·BioMed Research International·Antje Damms-MachadoStephan C Bischoff

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Citations

Apr 10, 2017·Molecular Aspects of Medicine·Vance L AlbaughCharles R Flynn
Jan 20, 2018·American Journal of Physiology. Gastrointestinal and Liver Physiology·Meng WeiSan-Yuan Hu
Apr 11, 2018·Current Obesity Reports·Caroline A AndrewAlpana P Shukla
Dec 28, 2017·Obesity Surgery·Kiminori WatanabeMasafumi Inomata
Jan 5, 2018·Diabetology & Metabolic Syndrome·Paul M RyanNoel M Caplice
May 31, 2016·F1000Research·Vance L AlbaughNaji N Abumrad
Aug 21, 2018·Endocrine Reviews·Emmanuel Somm, François R Jornayvaz
Feb 20, 2019·American Journal of Physiology. Endocrinology and Metabolism·Kristen E SyringOwen P McGuinness
Jun 20, 2019·The British Journal of Surgery·S AhlinJ J Nolan
Nov 27, 2019·Medicina·Adriana Florinela CӑtoiAndra Diana Andreicuț
Nov 23, 2017·Clinical Chemistry·Piriyah SinclairCarel W le Roux
Mar 19, 2020·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·Stephanie Sik Yu SoHani El-Nezami
Feb 19, 2020·American Journal of Physiology. Endocrinology and Metabolism·David A HarrisEric G Sheu
Jun 9, 2020·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·Stephanie Sik Yu SoHani El-Nezami
Feb 14, 2017·Journal of Translational Internal Medicine·Gerald H Tomkin, Daphne Owens
Jul 1, 2020·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·Shahab Alizadeh
Apr 23, 2020·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Aleksander EikenCarsten Dirksen
Mar 4, 2021·Nutrients·Dimitris Papamargaritis, Carel W le Roux
Jul 9, 2021·Journal of Obesity·Hatem ElgoharyWael Omar
Jul 15, 2021·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·Siavash BabajafariSeyed Mohammad Mazloomi
Aug 8, 2021·Nature Communications·Nadejda Bozadjieva-KramerRandy J Seeley

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