Changes in biliary excretory mechanisms in bile duct-ligated rat

Digestive Diseases and Sciences
H TakikawaM Yamanaka

Abstract

The effects of bile duct ligation on biliary excretion of bile acids, glutathione, and lipids were studied in the rat. The bile duct of the rat was ligated for three days. The biliary bile acid excretion after bile duct cannulation was higher at first, but after 90 min became lower than that in the control rat. The bile flow in the bile duct-ligated rat was higher after bile duct cannulation and gradually decreased to the same level as in the control rat. Biliary glutathione excretion, which has been suggested to be a driving force for the bile acid-independent canalicular bile flow, was markedly decreased in the bile duct-ligated rat. The mannitol clearance was increased and the bile ductules showed proliferation in the bile duct-ligated rat, suggesting an increase in the ductular bile flow. Biliary excretion of lithocholate glucuronide was more markedly impaired than that of taurocholate. When taurocholate was infused at higher rates, which increases bile flow and biliary excretion of bile acid and lipids in the control rat, biliary bile acid and lipid excretion remained constant in the bile duct-ligated rat. These findings indicate that, in the bile duct-ligated rat, the ductular bile flow was increased and bile acid-indepen...Continue Reading

References

Aug 1, 1991·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·H TakikawaO Tagaya
Aug 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·T NishidaI M Arias
Oct 1, 1991·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Y AdachiT Yamamoto
Apr 30, 1991·Biochemical and Biophysical Research Communications·K KobayashiK Hayashi
Jul 1, 1991·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M DumontS Erlinger
May 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·T KitamuraI M Arias
Jun 1, 1989·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·R P Oude ElferinkP L Jansen
May 1, 1988·The Journal of Clinical Investigation·F KuipersR J Vonk
Mar 1, 1972·The American Journal of Physiology·R D SolowayF P Brooks
Aug 1, 1970·The American Journal of Physiology·S ErlingerM Dumont
Apr 1, 1968·The American Journal of Physiology·W G Hardison, J C Norman
May 1, 1966·The American Journal of Physiology·H O Wheeler, P L Mancusi-Ungaro
Jul 1, 1993·Journal of the Experimental Analysis of Behavior·L V Panlilio, S J Weiss
Jun 1, 1993·The Journal of Clinical Investigation·R BossardP J Meier

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Citations

Mar 17, 2000·Journal of Gastroenterology and Hepatology·F KimuraK Nakagawa
Jun 11, 2003·Journal of Gastroenterology and Hepatology·Makoto HojoHajime Takikawa
Apr 30, 1999·Journal of Gastroenterology and Hepatology·H TakikawaM Yamanaka
Jun 16, 2005·Journal of Gastroenterology and Hepatology·Hiroko KuriharaHajime Takikawa
Dec 12, 2007·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Masaki Mikami, Hajime Takikawa
Mar 12, 2004·Journal of Gastroenterology and Hepatology·Naoko HanawaHajime Takikawa
Aug 12, 2004·Journal of Gastroenterology and Hepatology·Hidetaka TachizawaHajime Takikawa
Apr 28, 2005·Journal of Gastroenterology and Hepatology·Motoe TakayanagiHajime Takikawa
Mar 6, 2009·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Yoshihiko Morisawa, Hajime Takikawa

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