Changes in biochemical markers of joint tissue metabolism in a randomized controlled trial of glucocorticoid in early rheumatoid arthritis

Arthritis and Rheumatism
M SharifJ R Kirwan

Abstract

To determine the effects of low-dose prednisolone on joint tissue metabolism in early rheumatoid arthritis (RA). In addition to a range of biochemical markers of cartilage, bone and synovial tissue turnover, levels of pro-matrix metalloproteinase 3 (pro-MMP-3), pro-MMP-1, and cytidine deaminase (CD) were measured in serum from 79 of 128 patients with early RA who took part in the Arthritis and Rheumatism Council Low-Dose Glucocorticoid Study. Serum concentrations of joint tissue metabolites on treatment and off treatment were compared using Student's t-test. Levels of the keratan sulfate epitope, 5D4, and glycosaminoglycan (GAG) were similar on and off treatment. However, the levels of synovium-derived markers, hyaluronate (HA) and N-propeptide of type III procollagen (PIIINP), were reduced by 23.9% (P < 0.01) and 25.2% (P < 0.001), respectively, during treatment with prednisolone. Serum osteocalcin (OC) was reduced by 25.8% (P < 0.001), while the levels of CD and pro-MMP-3 increased by 31.2% (P < 0.01) and 53.7% (P < 0.001) during prednisolone treatment compared with the off-treatment period. Low-dose prednisolone had no significant effect on markers of cartilage turnover (GAG, 5D4) in early RA, suggesting that early erosions ...Continue Reading

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Citations

Oct 18, 2002·Arthritis and Rheumatism·Larry W Moreland, James R O'Dell
May 18, 1999·Current Opinion in Rheumatology·H W Woitge, M J Seibel
May 10, 2000·Current Opinion in Rheumatology·F A Wollheim
Jun 2, 2001·Annals of the Rheumatic Diseases·S A Young-MinI D Griffiths
Mar 7, 2014·Nihon Rinshō Men'eki Gakkai kaishi = Japanese journal of clinical immunology·Kouhei Miyake, Takayuki Katsuyama
Dec 1, 2001·Scandinavian Journal of Rheumatology·J S JohansenM Sharif
Jan 12, 2008·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Norbert WildWerner Zolg
Dec 1, 2007·Arthritis and Rheumatism·C R DavisM Sharif
Jun 9, 2001·Rheumatic Diseases Clinics of North America·J R Kirwan
Feb 19, 2013·International Journal of Cardiology·Mitsuaki Isobe
Jan 20, 2004·Arthritis and Rheumatism·John R Kirwan
Sep 7, 2018·International Journal of Rheumatic Diseases·Masahiro TadaNoriaki Hidaka
Sep 4, 2003·Circulation·Akifumi MatsuyamaYuji Matsuzawa
Mar 4, 2014·The Journal of Rheumatology·Maria-Antonietta D'AgostinoPhilip G Conaghan
Mar 22, 2021·Arthritis Research & Therapy·Jun IshizakiUNKNOWN Research Committee of Intractable Vasculitis Syndrome and the Research Committee of Intractable Renal Disease of the Ministr

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