Changes in biochemical markers of osteoblastic activity during the menstrual cycle

The Journal of Clinical Endocrinology and Metabolism
H K NielsenL Mosekilde

Abstract

Serum levels of osteocalcin [OC; bone Gla protein (BGP)] and bone alkaline phosphatase (B-AP) are both correlated to osteoblastic activity, which may be regulated by several hormones, including estrogen, 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3], and PTH. Estrogen shows reproducible variations during the menstrual cycle, while available data on variations in serum 1,25-(OH)2D3 and serum immunoreactive PTH show midcyclic increases or no changes. In the present study we evaluated osteoblastic activity by measuring serum OC and B-AP during the menstrual cycle in eight healthy women, aged 20-47 yr. The cycles were synchronized by LH peaks, and follicular and luteal periods were normalized by lengths. Repeated measures analysis of variance showed that serum OC varied significantly (P less than 0.05), with highest levels during the luteal period. Although the same pattern was seen for serum B-AP, the variation just failed to reach significance (P less than 0.10), but the mean level was significantly higher during the luteal than during the follicular period (P less than 0.05). Gonadotropins and ovarian sex hormones showed significant variations. There were no significant changes in serum vitamin D-binding protein, serum total and free ...Continue Reading

Citations

Aug 1, 1995·Calcified Tissue International·I GoraiH Minaguchi
Mar 13, 2013·Journal of Bone and Mineral Metabolism·Bruno MozzanegaGiovanni Battista Nardelli
May 1, 1994·Clinica Chimica Acta; International Journal of Clinical Chemistry·S B Rosalki
Mar 1, 1992·The Journal of Steroid Biochemistry and Molecular Biology·J Verhaeghe, R Bouillon
May 1, 1995·Bone·P GarneroP D Delmas
Dec 14, 2011·Human Reproduction·SiHyun ChoByung Seok Lee
Jan 1, 1997·The American Journal of the Medical Sciences·M Notelovitz
Sep 1, 1995·Medicine·K A Carmichael, D H Carmichael
Sep 24, 1999·Current Opinion in Nephrology and Hypertension·S M Hart, R Eastell
Feb 12, 2010·International Journal of Endocrinology·William B HallRobert M Aris
Aug 30, 2013·Journal of Translational Medicine·Gillian WheaterJacob M van Laar
May 11, 1999·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·K M ChiuC D Arnaud
Nov 5, 1999·Journal of Clinical Densitometry : the Official Journal of the International Society for Clinical Densitometry·P D MillerN B Watts
Nov 6, 2010·Journal of Osteoporosis·Vanadin Seifert-Klauss, Jerilynn C Prior
Mar 19, 2014·International Journal of Molecular Sciences·Jinzhong TaoYong Zhang
May 27, 2015·Journal of Sports Sciences·Jamie Reiger, Vanessa R Yingling
May 6, 2008·Journal of Clinical Densitometry : the Official Journal of the International Society for Clinical Densitometry·A I SebbaP Weissman
Oct 24, 2006·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Lars RejnmarkLeif Mosekilde
Jun 25, 2008·Annals of the New York Academy of Sciences·Barbara A Cromer
Dec 14, 2004·Women's Health Issues : Official Publication of the Jacobs Institute of Women's Health·Christine L Hitchcock, Jerilynn C Prior
Dec 1, 1991·Baillière's Clinical Obstetrics and Gynaecology·P D Delmas
Dec 31, 1997·The American Journal of Medicine·D D Bikle
Jan 18, 2008·American Journal of Obstetrics and Gynecology·Susan Thys-JacobsJohn P Bilezikian
Jan 9, 2014·Annals of Clinical Biochemistry·Thinn Thinn Hlaing, Juliet E Compston
May 6, 2003·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·M R SowersB Ettinger
Jun 15, 1993·Analytical Chemistry·N A McCarroll
Nov 25, 1991·The American Journal of Medicine·P D Delmas
Sep 5, 2006·American Journal of Veterinary Research·Brendan F JacksonJoanna S Price
May 4, 2005·Journal of the Society for Gynecologic Investigation·Simone FerreroJurgis G Grudzinskas
Jul 3, 2018·Climacteric : the Journal of the International Menopause Society·J C Prior
Jul 3, 2018·Climacteric : the Journal of the International Menopause Society·J C Prior
Jan 12, 2007·Journal of Medical Primatology·Ivo H MachatschkeBernard Wallner
Mar 20, 1999·The Journal of Clinical Endocrinology and Metabolism·C MassafraF Bagnoli
Jan 1, 1991·Critical Reviews in Clinical Laboratory Sciences·M J Power, P F Fottrell
Jul 22, 2008·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Gioia Di GiovanniPanagiota Klentrou
Sep 1, 2008·Expert Review of Endocrinology & Metabolism·Elisa Bocchieri, Susan Thys-Jacobs
May 26, 2012·Clinical Chemistry and Laboratory Medicine : CCLM·Giovanni LombardiGiuseppe Banfi
Dec 22, 1999·The Journal of Clinical Endocrinology and Metabolism·L A SoykaA Klibanski
Jun 18, 1999·The Journal of Clinical Endocrinology and Metabolism·B J Orr-WalkerI R Reid
Aug 10, 2000·Medicinal Research Reviews·L ProkaiN Bodor

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