Feb 15, 1980

Changes in blood-brain permeability resulting from D-amphetamine, 6-hydroxydopamine and pimozide measured by a new technique

U BraunT Sargent


A new technique is described for measurement of diffusion across the blood-brain barrier using intraventricularly administered 68Ga-EDTA, and determining loss from the brain with a scintillation camera. Repeated injections via permanent cannulas showed that the diffusion half-time was reduced to 50% of control values after intraventricular d-amphetamine and 6-hydroxydopamine; pimozide had no effect.

Mentioned in this Paper

Blood - Brain Barrier Anatomy
Gallium Radioisotopes
Edetic Acid, Sodium Salt
In Blood

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