Changes in blood chemistry, hematology, and histology caused by a selenium/vitamin E deficiency and recovery in chicks

Biological Trace Element Research
A BartholomewD E Swayne

Abstract

Exudative diathesis, a condition caused by a selenium (Se)/vitamin E deficiency, was studied in chicks. Trios of chicks that showed clinical signs of exudative diathesis were matched for severity. One was injected subcutaneously with 0.5 mL distilled water, and the other two received 15 microg of Se in 0.5 mL distilled water. A chick fed a diet with supplemental Se also received 0.5 mL distilled water. Blood was collected from three chicks 2 d after injection, and from the other chick, 6 d after injection. After blood was collected, pectoral muscle and bone marrow were collected. Deficient chicks showed varying degrees of necrosis in pectoral muscle, whereas recovering chicks had extensive fibrosis in pectoral muscle. An analysis of blood showed differences in CO2, glucose, Se, glutathione peroxidase, alanine aminotransferase, aspartate aminotransferase, and creatine kinase. Heterophils and monocytes were increased in deficient chicks; lymphocytes, basophils, and hemoglobin decreased. After 6 d of recovery, all of the changes noted above were correcting toward normal. Eosinophils, in contrast, were unaffected by a deficiency, but increased in recovering chicks. It is hypothesized that cytokines associated with the inflammatory ...Continue Reading

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Citations

Apr 27, 2011·Biological Trace Element Research·Dong YuShiwen Xu
Aug 13, 2011·Biological Trace Element Research·Hongfeng RuanShiwen Xu
Feb 12, 2014·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Dong YuShi-Wen Xu
Nov 12, 2013·Animal Science Journal = Nihon Chikusan Gakkaihō·Hachiro KamadaMasahiro Amari
Jul 26, 2005·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Viviane A NunesMariana S Araujo
Oct 30, 2014·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Dong YuShi-Wen Xu
Jul 30, 2003·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·V A NunesM S Araújo
Apr 20, 2002·European Journal of Clinical Nutrition·R D Semba, M W Bloem

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