Changes in blood coagulation of arm and leg veins during a simulated long-haul flight

Thrombosis Research
Wolfgang SchobersbergerWerner Streif

Abstract

Long-haul flights are associated with an increased incidence for venous thromboembolic events. At present, markers of coagulation and fibrinolysis were only analyzed from arm veins after long distance travel. Respective data from leg veins are missing. Here, we measured these parameters in healthy volunteers (n=12) before and after 10 h sitting in modern aircraft chairs under normobaric hypoxia (corresponding to 2400 m altitude). Blood was collected from arm and leg veins before, immediately after and 1 day after sitting in the hypoxic chamber. We did not find any evidence for a significant intravasal thrombin and fibrin formation and a changed fibrinolytic activity, neither in arm nor in leg vein blood. TAT, PAP, and PAI-1 remained unchanged, and the increases of F1+2 in arm veins and of d-dimer in leg veins were within the upper reference limits. Moreover, there was no evidence of activation of coagulation as measured by thrombelastography (ROTEM(R)) and the new Thrombin Dynamic Test at both locations. There was no evidence of arm or leg hemoconcentration. In healthy volunteers, prolonged sitting in ergonomically superior aircraft seats does not induce significant changes in blood coagulation and fibrinolysis in venous blood ...Continue Reading

References

Jan 11, 2001·Thrombosis Research·M HitosugiA Takatsu
Apr 6, 2001·Lancet·S Ozsoylu
Sep 15, 2001·The New England Journal of Medicine·F LapostolleF Adnet
Oct 3, 2003·Journal of Thrombosis and Haemostasis : JTH·P D HodkinsonJ Ernsting
Nov 8, 2003·BMJ : British Medical Journal·C W KelmanC D J Holman
Dec 10, 2003·Archives of Internal Medicine·Thomas SchwarzSebastian M Schellong
Dec 10, 2003·Archives of Internal Medicine·Esteban Pérez-RodríguezRoger D Yusen
Dec 10, 2003·Archives of Internal Medicine·Ida MartinelliPier Mannuccio Mannucci
Apr 17, 2004·British Journal of Haematology·Thomas G DeLougheryDavid Sauer
Jun 19, 2004·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Wolfgang SchobersbergerDietmar Fries
Feb 12, 2005·Seminars in Thrombosis and Hemostasis·Alexander S Gallus
Jun 28, 2005·Journal of Thrombosis and Haemostasis : JTH·H BoccalonJ B Ruidavets
Aug 24, 2005·British Journal of Haematology·Y-L Chee, H G Watson

❮ Previous
Next ❯

Citations

Sep 12, 2014·High Altitude Medicine & Biology·David A Rubenstein, Wei Yin
Dec 7, 2007·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Giuseppe LippiGian Cesare Guidi
Nov 7, 2006·Thrombosis Research·Jyoti KotwalJ Jayaram
Mar 23, 2012·Thrombosis and Haemostasis·Daniel S MartinUNKNOWN Caudwell Xtreme Everest Research Group
Jan 22, 2008·Surgical Neurology·Alessandro PerinPierluigi Longatti
Oct 10, 2015·BioMed Research International·Marc SchaberWolfgang Schobersberger
Aug 16, 2016·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Ozan KocakAyten Yakut
Nov 21, 2013·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Henry T Peng, Shawn G Rhind
Nov 15, 2013·Circulation·Therese M GigliaUNKNOWN American Heart Association Congenital Heart Defects Committee of the Council on Cardiovascular Disease in the Young, Council
Apr 16, 2010·Surgical Laparoscopy, Endoscopy & Percutaneous Techniques·Gamal KhairyAbdel Galil Mohammad Abdel Gader
Dec 4, 2009·Expert Review of Cardiovascular Therapy·Wolfgang SchobersbergerHugo Partsch
Nov 30, 2019·Journal of Travel Medicine·Divya J KarsanjiLeslie Skeith
Sep 5, 2015·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Daniel T RedfordVance G Nielsen
May 16, 2018·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Olga Meltem Akay
Feb 27, 2013·Medicine and Science in Sports and Exercise·Bethany J HowardBronwyn A Kingwell

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.