PMID: 9420882Nov 1, 1995Paper

Changes in blood flow to the ovine chorion and amnion across gestation

Journal of the Society for Gynecologic Investigation
H L HedrianaW M Gilbert

Abstract

The purpose of this study was to determine the developmental changes in blood flow to the network of fetal microvessels in ovine chorion and amnion. Colored microspheres (15.10 +/- 0.02 [standard deviation] mu in diameter) were infused into the superior vena cava in nine chronically catheterized fetal sheep with gestational ages ranging from 103-141 days (term 147). After euthanasia, chorion, amnion, and cotyledons were separated and microspheres were counted to determine blood flow rates. Standard correlation and regression analyses were used to analyze the data. Chorionic blood flow rate increased linearly (r = 0.82, P = .006) from 12 mL/minute at 103 days' gestation to 70 mL/minute at 141 days, and averaged 10.3 +/- 1.2% of the total umbilical blood flow. Weight-normalized chorionic flow (18.4 +/- 2.0 [standard error] mL/minute/kg of fetus) did not change significantly across gestation. Absolute and weight-normalized blood flow to the amnion (0.82 +/- 0.31 mL/minute and 0.34 +/- 0.11 mL/minute/kg fetus) increased with advancing gestation until 130 days and declined thereafter. Absolute cotyledonary blood flow rate increased with gestational age (r = 0.81, P = .008), and weight-normalized cotyledonary blood flow decreased wit...Continue Reading

Citations

Jan 24, 2012·American Journal of Physiology. Heart and Circulatory Physiology·Monique Y RennieJohn G Sled
Mar 26, 2005·The Journal of Physiology·Dino A GiussaniAbigail L Fowden
Feb 22, 2012·Molecular Aspects of Medicine·Dan ZhangHe-Feng Huang
Jan 8, 2004·American Journal of Obstetrics and Gynecology·Lowell E DavisRobert A Brace
Oct 22, 2002·American Journal of Obstetrics and Gynecology·Stephanie E MannRobert N Taylor
Oct 30, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Qin YangD Anderson
Mar 29, 2013·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Dan Rurak, Natalee W Bessette

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.