Changes in blood leukocyte distribution during double-blind, placebo-controlled food challenges in children with atopic dermatitis and suspected food allergy

International Archives of Allergy and Immunology
K BeyerB Niggemann

Abstract

The development of clinical reactions to food antigens is associated with cellular changes. The aim of this study was to determine whether the clinical outcome of double-blind, placebo-controlled food challenges would correlate with changes in blood leukocyte distribution. Double-blind, placebo-controlled food challenges were performed in 17 children with atopic dermatitis sensitized to hen's egg or cow's milk and in 9 children with atopic dermatitis but not sensitized to food. Blood leukocyte distribution and lymphocyte subsets were determined prior to and 24 h after challenges. In food-sensitized children the numbers of leukocytes and lymphocytes decreased significantly after allergen challenge independent of the clinical outcome of the provocation (p < 0.002 in both cases). This decrease was seen in T (CD3+) and B (CD19+) cell subsets (p<0.007 and p<0.0005, respectively). The CD4/CD8 ratio increased (p<0.04). The number of memory cells (CD45R0) dropped (p<0.02 for CD4 and p<0.004 for CD8) and there was a loss of L-selectin (p<0.003 for CD4 and CD8). No changes in thrombocytes, neutrophils, eosinophils and basophils were observed. None of these changes were seen in the sensitized patients during placebo challenges or in the n...Continue Reading

Citations

Mar 6, 2002·Indian Journal of Pediatrics·Bodo Niggemann
Feb 25, 2000·Allergy·C BührerB Niggemann
Aug 17, 2006·The British Journal of Dermatology·S M Langan, H C Williams
Mar 28, 2017·The Journal of Allergy and Clinical Immunology·Peter KorosecMatija Rijavec
Sep 8, 2010·Journal of Pediatric Gastroenterology and Nutrition·Aron CsehGabor Veres
Jun 5, 2002·Current Opinion in Allergy and Clinical Immunology·Bodo Niggemann
Nov 24, 2004·Journal of Immunoassay & Immunochemistry·Z PourpakM Mahmoudi

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