Changes in blood pressure, blood flow towards the head and heart rate during 90 deg head-up tilting for 30 min in anaesthetized male rats

Experimental Physiology
Hironobu Nishimura, Masao Yamasaki

Abstract

What is the central question of this study? How does the baroreceptor reflex contribute to systemic blood pressure (BP) control during prolonged 90 deg head-up tilting (HUT) in unconscious rats? What is the main finding and its importance? In intact rats, heart rate (HR) increased after the transition to upright by HUT, and BP was maintained in this posture throughout the 30 min experimental period. After sinoaortic denervation, which results in lack of discharge of the baroreflex afferents, HR and BP decreased gradually during 30 min of 90 deg HUT, suggesting that the baroreceptor reflex is an important factor for maintenance of BP during long-term upright posture. Changes in cardiovascular parameters during prolonged 90 deg head-up tilting (HUT) in animals have not been elucidated in detail. We clarified changes in systemic blood pressure (BP), blood flow towards the head (BF) and heart rate (HR) and the role of the baroreceptor reflex after a transition from the supine posture to 90 deg HUT for 30 min in anaesthetized rats (n = 13). In control rats with the baroreceptor reflex afferents intact, mean BP and BF after the onset of 90 deg HUT decreased significantly by -15.4 ± 5.9 and -26.2 ± 11.5% at 2.9 ± 1.1 s (mean ± SD, n =...Continue Reading

References

Aug 1, 1979·The American Journal of Physiology·R A DampneyA Zanchetti
Jan 1, 1986·The American Journal of Physiology·H Hinghofer-Szalkay, M Moser
Jan 1, 1993·The American Journal of Physiology·N Terada, T Takeuchi
Jul 1, 1996·Journal of Applied Physiology·J C BuckeyC G Blomqvist
Mar 15, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Terry N Thrasher
Jul 26, 2002·The Japanese Journal of Physiology·Masao Yamasaki, Tsuyoshi Shimizu
Oct 23, 2002·Journal of Applied Physiology·Hidefumi WakiShin-Ichiro Katsuda
Dec 1, 1964·Circulation Research·E M KRIEGER
Sep 23, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Taro Miyahara GotohHironobu Morita
Dec 31, 2003·Brain Research Bulletin·Paola d'AscanioOttavio Pompeiano
May 8, 2004·Experimental Physiology·Terry N Thrasher
Apr 26, 2005·Acta Physiologica Scandinavica·H WakiT Shimizu
Nov 11, 2008·Neuroscience Letters·Hidefumi WakiMasanobu Maeda
Sep 9, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Toshinari AkimotoShigehiko Ogoh
Sep 17, 2011·Journal of Applied Physiology·Chikara AbeHironobu Morita
Sep 12, 2014·BioMed Research International·Shin-ichiro KatsudaTsuyoshi Shimizu

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.