PMID: 8944371Nov 1, 1996Paper

Changes in blood rheology caused by Crohn's disease

European Journal of Gastroenterology & Hepatology
G NovacekR Koppensteiner

Abstract

Patients with Crohn's disease (CD) are at increased risk for thromboembolism, and multifocal microvascular infarction has even been suggested as a pathogenetic mechanism in CD. Abnormalities in blood rheology may contribute to the thromboembolism. To assess blood rheology in CD patients. Prospective evaluation of rheological parameters. Out-patients at the gastroenterological department of a university hospital. Thirty-seven patients with inactive CD (Crohn's disease activity index (CDAI) < 150), 31 patients with active CD (CDAI > 150), and 39 control subjects with no CD were included in the study. C-reactive protein and orosomucoid were used as serum inflammatory parameters. Fibrinogen, red cell aggregation (low shear, 3/s) and plasma viscosity were used as rheological parameters. Fibrinogen (active CD: median 530 mg/dl (interquartile range 410-630); inactive CD: 377 (316-499); and controls: 246 (220-280)), red cell aggregation (active CD: 9.97 arb. units (8.58-11.77); inactive CD: 9.03 (7.25-10.37); controls: 7.58 (7-8.52)); and plasma viscosity (active CD: 1.82 mPa.s (1.68-1.95); inactive CD: 1.72 (1.65-1.82), controls: 1.61 (1.58-1.64)) were all significantly higher in patients with active and inactive CD than they were in ...Continue Reading

Citations

Jan 13, 2009·Inflammatory Bowel Diseases·Nitsan MaharshakIris Dotan
Feb 4, 2011·Inflammatory Bowel Diseases·Geoffrey C Nguyen
Apr 23, 2005·Digestive Diseases and Sciences·Liaz ZilbermanShlomo Berliner
Apr 16, 1999·Journal of Pediatric Gastroenterology and Nutrition·P WeberU Nowak-Göttl
May 9, 2006·Journal of Gastroenterology and Hepatology·Józef DrzewoskiLeszek Czupryniak
Mar 1, 2012·Journal of Oncology·Priya R PrabhuM Radhakrishna Pillai
Aug 15, 2014·Journal of Thrombosis and Thrombolysis·Darina KohoutovaJan Bures
Mar 23, 1999·The American Journal of Gastroenterology·G NovacekH Vogelsang
Nov 21, 2012·Journal of Pediatric Gastroenterology and Nutrition·Andrea DeutschmannWolfgang Muntean
Oct 12, 2004·Inflammatory Bowel Diseases·Gottfried NovacekHarald Vogelsang
Dec 23, 2003·The American Journal of Gastroenterology·Craig A SolemWilliam J Sandborn
Dec 2, 2020·Clinical and Translational Gastroenterology·Zsolt SzakácsJudit Bajor
Oct 7, 2005·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Peter M IrvingDavid S Rampton

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.