PMID: 11605923Oct 19, 2001Paper

Changes in blood volume and hematocrit during acute preoperative volume loading with 5% albumin or 6% hetastarch solutions in patients before radical hysterectomy

Anesthesiology
M RehmU Finsterer

Abstract

The impact of acute preoperative volume loading with colloids on blood volume has not been investigated sufficiently. Before surgery, in 20 patients undergoing major gynecologic procedures, volume loading was performed during anesthesia by infusing approximately 20 ml/kg of colloid at a rate of 90 ml/min (group I: 5% albumin solution; group II: 6% hetastarch solution; n = 10 each). Plasma volume (indocyanine green dilution technique), erythrocyte volume (labeling erythrocytes with fluorescein), hematocrit, total protein, and hetastarch plasma concentrations (group II) were measured before and 30 min after the end of infusion. More than 1,350 ml of colloid (approximately 50% of the baseline plasma volume) were infused within 15 min. Thirty minutes after the infusion had been completed, blood volume was only 524 +/- 328 ml (group I) and 603 +/- 314 ml (group II) higher than before volume loading. The large vessel hematocrit (measured by centrifugation) dropped more than the whole body hematocrit, which was derived from double-label measurements of blood volume. The double-label measurements of blood volume performed showed that 30 min after the infusion of approximately 20 ml/kg of 5% albumin or 6% hetastarch solution (within 15 ...Continue Reading

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Citations

Mar 30, 2006·Der Anaesthesist·M JacobM Rehm
Sep 24, 2008·Der Anaesthesist·D ChappellM Rehm
Feb 26, 2011·Der Anaesthesist·B NohéK Unertl
Sep 23, 2010·Basic Research in Cardiology·Bernhard F BeckerMatthias Jacob
Oct 19, 2010·Journal of Anesthesia·Tomi T NiemiMichiaki Yamakage
Oct 20, 2011·Annals of Biomedical Engineering·F E Curry, R H Adamson
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May 14, 2010·Cardiovascular Research·Bernhard F BeckerMatthias Jacob
Jun 8, 2013·Current Opinion in Critical Care·Matthias Jacob, Daniel Chappell
Aug 10, 2013·Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine·Daniel Chappell, Matthias Jacob
Jan 30, 2014·Perioperative Medicine·Takehiko IijimaChrister H Svensen
Sep 13, 2011·Annals of Intensive Care·Mike S StrundenDaniel A Reuter
May 18, 2012·Critical Care : the Official Journal of the Critical Care Forum·Matthias JacobMarkus Rehm
Mar 6, 2008·Critical Care : the Official Journal of the Critical Care Forum·Matthias JacobMarkus Rehm
May 22, 2007·Anesthesia and Analgesia·Jochen RennerBerthold Bein
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Mar 25, 2009·Current Opinion in Anaesthesiology·Daniel ChappellMatthias Jacob
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Aug 16, 2008·The Journal of Physiology·Daniel ChappellBernhard Friedrich Becker
Jan 29, 2013·Best Practice & Research. Clinical Anaesthesiology·Matthias Jacob, Daniel Chappell
Dec 17, 2014·Critical Care : the Official Journal of the Critical Care Forum·Daniel ChappellMarkus Rehm
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Aug 6, 2009·Best Practice & Research. Clinical Anaesthesiology·Matthias JacobMarkus Rehm
Aug 6, 2009·Best Practice & Research. Clinical Anaesthesiology·Christian ErtmerMartin Westphal
Aug 6, 2009·Best Practice & Research. Clinical Anaesthesiology·Martin WestphalBerthold Bein

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