Changes in bone histomorphometry after long-term treatment with intermittent, cyclic etidronate for postmenopausal osteoporosis

Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
T StormF Melsen

Abstract

Intermittent, cyclic etidronate therapy (400 mg/day for 2 weeks followed by 13 weeks free from study drug administration) resulted in a significant increase in lumbar bone mineral content and a significant decrease in the rate of new vertebral fractures in patients with postmenopausal osteoporosis. To investigate the effect of the treatment on bone histomorphometry, transiliac crest bone biopsy samples were obtained in this study before treatment and after 60 and 150 weeks of treatment with either intermittent, cyclic etidronate (n = 33) or placebo (n = 33). After 60 weeks of etidronate therapy, significant decreases in activation frequency (from 0.55 to 0.09 year,-1 P < 0.01) and resorption depth (from 53.2 to 37.8 microns, P < 0.05) were observed, leading to a positive balance per remodeling cycle. In the placebo group, no significant changes were seen. The 150 week bone biopsy samples were suboptimal for analysis, probably as a result of a regional acceleratory phenomenon. Our results suggest that, as a result of reductions in both activation frequency and resorption depth, intermittent, cyclic etidronate therapy may protect the trabecular network against fortuitous perforations and thereby maintain the strength of the bony ...Continue Reading

References

Dec 8, 1978·Calcified Tissue Research·F Melsen, L Mosekilde
Nov 1, 1976·Clinical Pharmacology and Therapeutics·R P Heaney, P D Saville
Jul 12, 1990·The New England Journal of Medicine·N B WattsM J Yanover
Apr 1, 1990·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·E F EriksenB L Riggs
Apr 1, 1989·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·L E MalletteJ I Mechanick
Dec 23, 1989·Lancet·J Y ReginsterP Franchimont
Apr 1, 1988·The Journal of Clinical Endocrinology and Metabolism·R PacificiL V Avioli
Dec 1, 1987·Clinical Obstetrics and Gynecology·A M Parfitt
Jan 1, 1969·Calcified Tissue Research·H M Frost
Apr 1, 1966·The Journal of Pathology and Bacteriology·J Ball, A Garner
Sep 11, 1982·Lancet·C Nagant de DeuxchaisnesJ P Devogelaer
Jan 1, 1981·Metabolic Bone Disease & Related Research·H Fleisch
May 1, 1984·Calcified Tissue International·C AndersonB M Wolfe
Jan 1, 1983·Metabolic Bone Disease & Related Research·J KragstrupL Mosekilde
Jan 1, 1981·Metabolic Bone Disease & Related Research·L FloraA R Villanueva
Jan 1, 1982·Metabolic Bone Disease & Related Research·J KragstrupL Mosekilde
Jan 1, 1952·Acta Anatomica·R AMPRINO, A ENGSTROM

❮ Previous
Next ❯

Citations

Dec 29, 2000·Journal of Hepatology·K D LindorE R Dickson
Aug 15, 2003·Clinics in Geriatric Medicine·Nelson B Watts
Jul 21, 1998·Endocrinology and Metabolism Clinics of North America·N B Watts
Jan 30, 2004·The Spine Journal : Official Journal of the North American Spine Society·Ronald A LehmanK Daniel Riew
Nov 26, 1997·Annals of the Rheumatic Diseases·J H Tobias
Sep 17, 1994·BMJ : British Medical Journal·J E Compston
Jun 15, 1996·The Journal of Clinical Investigation·G A Rodan, H A Fleisch
Nov 24, 1999·The Journal of Clinical Investigation·L I PlotkinT Bellido
Aug 27, 2010·Arthritis Research & Therapy·Maria Teresa ValentiLuca Dalle Carbonare
Jan 1, 2010·Drug, Healthcare and Patient Safety·Luca Dalle CarbonareMaria Teresa Valenti
Jun 20, 2014·Cell Communication & Adhesion·Pooyan Sadr-EshkevariNora Prochnow
May 20, 2016·Acta Orthopaedica·Terhi J HeinoVille-Valtteri Välimäki
Feb 6, 2003·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Xiaodu Wang, Qingwen Ni
Oct 20, 2015·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Justyna J Miszkiewicz, Patrick Mahoney
Apr 26, 2000·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·T MashibaD B Burr
Apr 1, 1996·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·M C Monier-FaugereH H Malluche
Feb 1, 1995·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·R W BoyceE F Eriksen
Jun 1, 1995·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·T KatsumataT Sakurama
May 1, 1995·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·P FilipponiS Cristallini
Feb 1, 1996·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·A M ParfittB F Boyce
Nov 1, 1993·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·M C Monier-FaugereH H Malluche
May 4, 2010·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Vassilios VassiliouDimitrios Kardamakis
Mar 1, 1994·Calcified Tissue International·M E LacyA D Geddes
May 1, 1994·Calcified Tissue International·N GuañabensJ Muñoz-Gómez
Mar 12, 1998·Endocrine Reviews·H Fleisch
Feb 5, 1999·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·T ThomasM H Lafage-Proust
Nov 22, 2001·Pharmazie in unserer Zeit·H Fleisch
Apr 19, 2017·Calcified Tissue International·Rosie PitfieldPatrick Mahoney
Mar 29, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J Pfeilschifter, I J Diel
Jan 29, 2002·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Susan M OttPaul Lips
Jul 12, 2002·Journal of Endocrinological Investigation·O Fromigué, J J Body
Aug 1, 1997·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·D W Dempster
Nov 5, 1998·Aging : Clinical and Experimental Research·S E Papapoulos
Nov 24, 1998·Aging : Clinical and Experimental Research·C Gennari, J Y Reginster

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.