Changes in bone marrow inflammatory cell progenitors after inhaled allergen in asthmatic subjects

American Journal of Respiratory and Critical Care Medicine
L J WoodPaul M O'Byrne

Abstract

Increases in inflammatory cell progenitors, particularly eosinophil/basophil colony-forming cells (Eo/B-CFU), occur in peripheral blood after allergen provocation. The role of bone marrow (BM) in these reactions is unclear. We examined the effect of allergen challenge on human bone marrow progenitor cell growth. Fifteen asthmatic subjects, eight dual responders (DR) and seven isolated early responders (IER), were challenged with inhaled allergen. BM aspirates were taken before and 24 h after challenge and progenitors were enumerated by a colony-forming assay. Eo/B-CFU numbers increased in both groups after allergen challenge (p < 0.0001). For DR, the increases were significant for BM incubated with optimal GMCSF and IL-5, but not with IL-3. For IER, the increases were significant for all three cytokines tested. At a suboptimal concentration of IL-5, there was a significant increase in the number of Eo/B-CFU after allergen in the DR, from 5.25 +/- 1.2 to 9.68 +/- 2.1 per 2.5 x 10(5) cells plated (p < 0.01), which was not demonstrated in the IER (p = 0.94). The responses at this concentration of IL-5 were different between groups (p < 0.05). These results demonstrate that inhaled allergen increases BM Eo/B-CFU, and that the bone ...Continue Reading

References

Jun 1, 1992·The American Review of Respiratory Disease·I PinF E Hargreave
Jul 1, 1992·The American Review of Respiratory Disease·A R GulbenkianA S Watnick
Aug 1, 1991·The American Review of Respiratory Disease·R AalbersJ G De Monchy
Nov 1, 1990·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·P G GibsonJ A Denburg
Oct 11, 1990·The New England Journal of Medicine·J BousquetP Godard
Jun 1, 1989·The American Review of Respiratory Disease·P DiazA B Kay
May 1, 1989·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·J A DenburgD Harnish
Sep 1, 1987·The American Review of Respiratory Disease·P M O'ByrneF E Hargreave
Aug 1, 1986·The Journal of Allergy and Clinical Immunology·H OtsukaJ A Denburg
Sep 1, 1985·The Journal of Allergy and Clinical Immunology·J A DenburgJ Bienenstock
Dec 1, 1993·The American Review of Respiratory Disease·P J MauserW Kreutner
May 1, 1995·International Archives of Allergy and Immunology·R W EganM W Bodmer
Aug 1, 1995·American Journal of Respiratory and Critical Care Medicine·P J MauserR W Chapman
Nov 1, 1994·American Journal of Respiratory Cell and Molecular Biology·M J WoolleyP M O'Byrne
Aug 1, 1994·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·T PopovF E Hargreave
May 28, 1994·Annals of the New York Academy of Sciences·M LavioletteL P Boulet
Feb 1, 1994·Respiratory Medicine·E J WeersinkJ G de Monchy
May 1, 1994·The Journal of Allergy and Clinical Immunology·A Girgis-GabardoJ Dolovich
Nov 1, 1996·American Journal of Respiratory and Critical Care Medicine·G M GauvreauP M O'Byrne
Nov 1, 1996·American Journal of Respiratory Cell and Molecular Biology·R SehmiJ A Denburg
Sep 1, 1996·American Journal of Respiratory Cell and Molecular Biology·M D InmanP M O'Byrne

❮ Previous
Next ❯

Citations

Dec 6, 2003·The Journal of Allergy and Clinical Immunology·Larry Borish
Aug 7, 2002·Pharmacology & Therapeutics·Adrian J BaatjesJudah A Denburg
Jan 6, 2009·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Mary Beth HoganKenneth S Landreth
Nov 28, 2002·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Paul A Greenberger
Apr 3, 2002·Trends in Molecular Medicine·Paul S FosterDianne C Webb
Jul 28, 1999·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·P M O'ByrneL J Wood
Mar 27, 2001·Immunology and Cell Biology·D H Yates
Jan 5, 2005·The Journal of Experimental Medicine·Hiromasa InoueAkihiko Yoshimura
Dec 26, 2001·Current Opinion in Pulmonary Medicine·Andrew Menzies-Gow, Douglas S Robinson
Oct 27, 1998·Allergy·P M O'ByrneL J Wood
Jun 14, 2000·American Journal of Respiratory and Critical Care Medicine·J S Erjefält, C G Persson
Mar 22, 2003·American Journal of Respiratory and Critical Care Medicine·Johan C KipsRomain A Pauwels
Nov 25, 2003·American Journal of Respiratory and Critical Care Medicine·Sandra C DormanRoma Sehmi
Dec 6, 2003·American Journal of Respiratory and Critical Care Medicine·Sandra C DormanPaul M O'Byrne
Jan 27, 2004·American Journal of Respiratory and Critical Care Medicine·Krishnan ParameswaranPaul M O'Byrne
Feb 3, 2007·American Journal of Respiratory and Critical Care Medicine·Harsha H KariyawasamA Barry Kay
Sep 17, 2002·American Journal of Respiratory and Critical Care Medicine·Lorna J WoodPaul M O'Byrne
Sep 30, 1999·American Journal of Respiratory Cell and Molecular Biology·M D InmanP M O'Byrne
Sep 30, 1999·American Journal of Respiratory Cell and Molecular Biology·P S Foster
Aug 16, 2003·American Journal of Respiratory Cell and Molecular Biology·Brigita SitkauskieneJan Lötvall
Jun 3, 2006·Respiratory Research·Madeleine RådingerJan Lötvall
Jul 30, 2011·Trends in Immunology·Deborah H Strickland, Patrick G Holt
Oct 6, 2009·International Immunopharmacology·Nadia S MarianoEdson Antunes
Dec 9, 2008·Pharmacology & Therapeutics·Madeleine Rådinger, Jan Lötvall
Jul 23, 2009·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·G M GauvreauJ A Denburg
May 15, 2009·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·A I FanatR Sehmi
Feb 4, 2009·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·P M O'ByrneJ D Brannan
Oct 11, 2014·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Guy W ScaddingMohamed H Shamji
Jul 28, 2004·Biochemical Pharmacology·Heloisa Helena de Araujo FerreiraGilberto De Nucci
Nov 5, 1999·American Journal of Orthodontics and Dentofacial Orthopedics : Official Publication of the American Association of Orthodontists, Its Constituent Societies, and the American Board of Orthodontics·S McNabA L Symons

❮ Previous
Next ❯

Related Concepts

Related Feeds

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Basophils

Basophils are myeloid cells with a high affinity IgE receptor and is involved in inflammatory responses during allergy. Discover the latest research on Basophils here.

American Thoracic Association Journals

Discover the latest respiratory research published by the journals from the American Thoracic Society.