Changes in bone metabolism after gastric cancer surgery in male patients: a prospective observational study

Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association
Yosuke AtsumiMunetaka Masuda

Abstract

Several retrospective studies have shown that bone disorders occur after gastric cancer surgery. This study was designed to prospectively evaluate the changes in bone metabolism after gastrectomy for gastric cancer. We prospectively enrolled 39 men with early gastric cancer who underwent gastrectomy. We excluded women to avoid the effects of menopause. We employed dual energy X-ray absorptiometry (DEXA) to measure bone mineral density (BMD) of the lumbar spine. DEXA was performed before and 1 and 2 years after surgery. The serum levels of alkaline phosphatase (ALP), 1,25-dihydroxy vitamin D [1,25(OH)2VD], 25-hydroxy vitamin D [25(OH)VD], and estradiol were measured before surgery and every 3 months until 2 years after surgery. DEXA revealed that BMD significantly decreased by 0.036 ± 0.033 g/cm2 12 months after gastrectomy (P < 0.001) and by 0.046 ± 0.040 g/cm2 24 months after gastrectomy (P < 0.001). The serum ALP level significantly increased by 38.31 ± 103.8 IU/L 24 months after surgery (P = 0.013). The serum 25(OH)VD level significantly decreased by 4.88 ± 6.42 ng/ml 24 months after surgery (P < 0.001), whereas the serum 1,25(OH)2VD levels were consistently in the normal range. The serum estradiol level significantly increa...Continue Reading

References

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Citations

Oct 27, 2020·JGH Open : an Open Access Journal of Gastroenterology and Hepatology·Tsutomu NamikawaKazuhiro Hanazaki
Feb 26, 2021·Surgery Today·Yasushi RinoNorio Yukawa
Jul 1, 2021·Surgery for Obesity and Related Diseases : Official Journal of the American Society for Bariatric Surgery·Mohammad Reza EmamiShahab Alizadeh

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