PMID: 7993527Aug 1, 1994Paper

Changes in brain and spinal cord water content during recurrent experimental autoimmune encephalomyelitis in female Lewis rats

Molecular and Chemical Neuropathology
E L OrrN C Stanley

Abstract

Regional changes in percent water content, a measure of regional levels of edema, were determined in female Lewis rats during key stages of recurrent experimental autoimmune encephalomyelitis (rEAE). The changes in percent water content of the spinal cord and brainstem closely paralleled the clinical and, to a lesser extent, histological course of rEAE (increasing during exacerbations and decreasing during remissions), whereas the percent water content of the forebrain, thalamus/midbrain, hypothalamus, and cerebellum remained constant and equal to control levels at all stages of the disease process. These results suggest that edema formation and resolution in the brainstem and spinal cord may be significant determinants of the transient and recurrent course of neurological dysfunction exhibited by rats with rEAE.

References

Sep 1, 1990·Journal of Neuroimmunology·N C StanleyE L Orr
Dec 1, 1985·Journal of Neuroimmunology·C FeurerS Cammisuli
Oct 1, 1974·Journal of Neuropathology and Experimental Neurology·W H Oldendorf, H F Towner
Nov 1, 1966·Proceedings of the Society for Experimental Biology and Medicine·S LevineE J Wenk
Jan 1, 1984·Journal of the Neurological Sciences·H ReiberM G Rumsby
Jan 1, 1960·Acta Psychiatrica Scandinavica·M Wender, M Hierowski

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Citations

Mar 21, 2007·Proceedings of the National Academy of Sciences of the United States of America·Marzena J FabisD Craig Hooper
Jul 31, 2004·Neuroscience·K OshioG T Manley
Mar 7, 2015·Neurochemistry International·Sveinung FjærStig Wergeland
Nov 25, 2014·Cellular and Molecular Life Sciences : CMLS·Markus KippOmid Nikoubashman
Aug 6, 2016·Journal of Molecular Neuroscience : MN·Nina WagenknechtMarkus Kipp
Sep 11, 2007·Acta Neurologica Scandinavica·C M Poser, V V Brinar
Nov 18, 2009·Clinical Anatomy : Official Journal of the American Association of Clinical Anatomists & the British Association of Clinical Anatomists·R ClaphamR O Carare

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