Changes in Brain Lateralization in Patients with Mild Cognitive Impairment and Alzheimer's Disease: A Resting-State Functional Magnetic Resonance Study from Alzheimer's Disease Neuroimaging Initiative

Frontiers in Neurology
Hao LiuQixiang Lin

Abstract

To detect changes in brain lateralization in patients with mild cognitive impairment (MCI) and Alzheimer's disease (AD) using resting-state functional magnetic resonance imaging (fMRI). Data from 61 well-matched right-handed subjects were obtained from the Alzheimer's Disease Neuroimaging Initiative, including 19 healthy controls (HCs), 25 patients with MCI, and 17 patients with AD. First, we divided 256 pairs of seed regions from each hemisphere covering the entire cerebral gray matter. Then, we used the intrinsic laterality index (iLI) approach to quantify the functional laterality using fMRI. One-way ANOVA was employed to estimate the differences in iLI among the three groups. The sum, number and mean value of the iLI were calculated within the thresholds of 0 < |iLI| < 0.2, 0.2 ≤ |iLI| < 0.4, 0.4 ≤ |iLI| < 0.8, and |iLI| ≥ 0.8, to explore the changes in the lateralization of resting-state brain function in patients with MCI and AD. One-way ANOVA revealed that the iLIs of the three groups were significantly different. The HCs showed a significant leftward interhemispheric difference within |iLI| ≥ 0.8. Compared with the HCs, the patients with MCI manifested a distinct abnormal rightward interhemispheric asymmetry, mainly wit...Continue Reading

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Citations

May 31, 2020·Journal of the American Geriatrics Society·Ryan McGrathBrian C Clark
Dec 24, 2018·Frontiers in Psychiatry·Li LinYing Han
Sep 26, 2019·Frontiers in Neurology·Alice D LamSydney S Cash
Jul 24, 2020·Scientific Reports·Holly C HunsbergerChristine Ann Denny
Apr 25, 2019·Brain Sciences·Katerina D TzimourtaMarkos G Tsipouras
Aug 20, 2021·Frontiers in Aging Neuroscience·Yi-Chia WeiChing-Po Lin
Nov 20, 2021·Journal of Intellectual Disability Research : JIDR·C MigliorelliÁ García-Cazorla

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Software Mentioned

Statistical Parametric Mapping software ( SPM8 )
iLI
- State fMRI Data Analysis Toolkit ( REST
Statistical Package for the Social Science ( SPSS
Resting
Data Processing Assistant for Resting - State fMRI

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