PMID: 9657Jul 9, 1976

Changes in brain norepinephrine associated with sensitization to d-amphetamine

Psychopharmacology
P H Short, L Shuster

Abstract

Pretreatment of B6AF1/J mice with d-amphetamine HCl 10 mg/kg, twice daily for 5 days, produced a 4-fold increase in the running response to a test dose of 5 mg/kg amphetamine. Amphetamine pretreatment decreased whole-brain norepinephrine levels to 50% of control values and whole-brain dopamine to 85%. The test dose of 5 mg/kg amphetamine lowered whole brain norepinephrine levels of control mice from 0.50 mug/g to 0.28 mug/g in 2 h. In amphetamine-pretreated mice, this injection caused an increase in whole-brain norepinephrine levels from 0.22 mug/g to 0.55 mug/g at 30 min, followed by a decrease to 0.22 mug/g at 60 min. No change in whole brain dopamine levels was observed in either group. Amphetamine sensitization and norepinephrine depletion were still evident 25 days after pretreatment. No cross sensitization to morphine or cocaine was observed. Reserpine pretreatment resulted in a 3-fold increase in locomotor activity following injection of d-amphetamine, 5 mg/kg. No sensitization or changes in catecholamine levels were observed in amphetamine-treated A/J mice. These results suggest that the sensitization produced by amphetamine pretreatment may be related to the depletion of brain norepinephrine.

References

Jun 19, 1975·Psychopharmacologia·L ShusterB E Eleftheriou
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Citations

Mar 14, 1979·Psychopharmacology·H Y MeltzerV S Fang
Jan 1, 1982·Psychopharmacology·L ShusterD Righi
Apr 29, 1977·Psychopharmacology·L ShusterA Bates
Apr 15, 1979·European Journal of Pharmacology·P Muller, P Seeman
May 1, 1977·Pharmacology, Biochemistry, and Behavior·R G Browne, D S Segal
Dec 1, 1981·Pharmacology, Biochemistry, and Behavior·M Hirabayashi, M R Alam
Sep 1, 1981·Pharmacology, Biochemistry, and Behavior·N J Leith, R Kuczenski
Jul 1, 1992·Pharmacology, Biochemistry, and Behavior·T YamamuraH Ouchi
Mar 1, 1996·Pharmacology, Biochemistry, and Behavior·G I ElmerR B Rothman
Sep 1, 1993·Brain Research. Brain Research Reviews·T E Robinson, K C Berridge
Jul 1, 1997·Pharmacology, Biochemistry, and Behavior·T J PhillipsC N Lessov
Jul 27, 1999·Pharmacology, Biochemistry, and Behavior·K K SzumlinskiS D Glick
Nov 21, 2001·Drug and Alcohol Dependence·H L KimmelM J Kuhar
Sep 1, 1997·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·D M CampT E Robinson
Jul 1, 1978·The Journal of Pharmacy and Pharmacology·C McManusP Seeman
May 1, 1993·The Journal of Pharmacy and Pharmacology·M Hirabayashi, S Tadokoro
Sep 25, 2010·The Journal of Pharmacology and Experimental Therapeutics·Barbara J CaldaroneAfshin Ghavami
Dec 17, 2008·Journal of Psychopharmacology·J A MilsteinT W Robbins

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