Changes in brain perfusion in successive arterial spin labeling MRI scans in neonates with hypoxic-ischemic encephalopathy

NeuroImage. Clinical
Maïa ProisyJean-Christophe Ferré

Abstract

The primary objective of this study was to evaluate changes in cerebral blood flow (CBF) using arterial spin labeling MRI between day 4 of life (DOL4) and day 11 of life (DOL11) in neonates with hypoxic-ischemic encephalopathy (HIE) treated with hypothermia. The secondary objectives were to compare CBF values between the different regions of interest (ROIs) and between infants with ischemic lesions on MRI and infants with normal MRI findings. We prospectively included all consecutive neonates with HIE admitted to the neonatal intensive care unit of our institution who were eligible for therapeutic hypothermia. Each neonate systematically underwent two MRI examinations as close as possible to day 4 (early MRI) and day 11 (late MRI) of life. A custom processing pipeline of morphological and perfusion imaging data adapted to neonates was developed to perform automated ROI analysis. Twenty-eight neonates were included in the study between April 2015 and December 2017. There were 16 boys and 12 girls. Statistical analysis was finally performed on 37 MRIs, 17 early MRIs and 20 late MRIs. Eleven neonates had both early and late MRIs of good quality available. Eight out of 17 neonates (47%) had an abnormal on late MRI as performed and ...Continue Reading

References

Jul 1, 1990·The Journal of Pediatrics·O PrydsB Friis-Hansen
Mar 1, 1985·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·P Herscovitch, M E Raichle
May 15, 1998·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·E C WongL R Frank
Sep 4, 1998·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·R B BuxtonR R Edelman
Jun 17, 1999·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·W M LuhJ S Hyde
Mar 18, 2006·Neuroimaging Clinics of North America·Jiongjiong Wang, Daniel J Licht
Jul 25, 2006·The British Journal of Radiology·E T PetersenX Golay
May 19, 2007·Pediatric Neurology·Carlos E A BatistaSeetha Shankaran
May 28, 2008·Journal of Magnetic Resonance Imaging : JMRI·Pia WintermarkReto Meuli
Jan 10, 2009·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Daniel Gallichan, Peter Jezzard
Feb 11, 2010·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Bradley J MacIntoshPeter Jezzard
Jul 30, 2010·NMR in Biomedicine·Marta VarelaDavid J Larkman
Sep 4, 2010·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·E Saliba, T Debillon
Oct 8, 2011·AJNR. American Journal of Neuroradiology·P WintermarkS K Warfield
Mar 16, 2013·AJNR. American Journal of Neuroradiology·A N MassaroC Limperopoulos
Mar 19, 2014·Magnetic Resonance Imaging·Camille MaumetChristian Barillot
Apr 10, 2014·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·David C AlsopGreg Zaharchuk
Aug 22, 2014·Journal of Magnetic Resonance Imaging : JMRI·Marta VarelaJoseph V Hajnal
Jan 22, 2015·Archives of Disease in Childhood. Fetal and Neonatal Edition·Elodie BoudesPia Wintermark
May 16, 2015·Scientific Data·Brian B AvantsDanny J J Wang
Apr 16, 2016·AJNR. American Journal of Neuroradiology·M ProisyJ-C Ferré
Jun 13, 2017·NeuroImage. Clinical·Domenico TortoraMassimo Caulo

❮ Previous
Next ❯

Citations

Jun 6, 2020·Frontiers in Pediatrics·Mary O'DeaEleanor J Molloy
Aug 2, 2021·Pediatric Radiology·Memduha GumusJudy H Squires
Aug 17, 2021·Seminars in Fetal & Neonatal Medicine·L ChalakUNKNOWN Newborn Brain Society Guidelines and Publications

❮ Previous
Next ❯

Methods Mentioned

BETA
imaging techniques

Software Mentioned

ALBERTs
Anima
SPM8
MedCalc
PICORE Q2TIPS
Matlab®
DOL4

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.