PMID: 2496079Feb 1, 1989Paper

Changes in breath 13CO2/12CO2 consequent to exercise and hypoxia

Journal of Applied Physiology
T J BarstowK Wasserman

Abstract

Because the natural enrichment of carbohydrate with 13C is greater than that of lipid, we hypothesized that the natural enrichment of exhaled CO2 with 13C (EN) could be used to gauge endogenous substrate utilization in exercising human subjects. To test this, EN and the respiratory exchange ratio (R) which equals the respiratory quotient (RQ) in the steady state, were measured simultaneously in seven subjects. Rest and exercise protocols, performed under conditions of room air (sea level) and hypoxic (inspired O2 fraction = 0.15) breathing, were chosen to cause a variety of patterns of oxidative substrate utilization. Work rates were performed both below and above the subject's lactate threshold (LT). Work above the LT was expected to cause the greatest increase in EN reflecting greater utilization of glucose. There was significant intersubject (P less than 0.05) but not intrasubject variability in resting EN. By 40 min of exercise, EN increased significantly (P less than 0.05) over resting values in all exercise protocols during both room air and hypoxia conditions. In the room air studies, we found no difference in EN during the below-LT work, even though there were significant increases in O2 uptake (VO2). In contrast, above...Continue Reading

Citations

Jan 1, 1993·European Journal of Applied Physiology and Occupational Physiology·D MassicotteC Hillaire-Marcel
Feb 5, 2009·Isotopes in Environmental and Health Studies·Robert HedgesWilliam Aalbersberg
Mar 19, 2020·Chembiochem : a European Journal of Chemical Biology·Antoine Danchin
Sep 30, 2016·Scientific Reports·Illa TeaGuillaume Tcherkez
Jan 1, 1994·European Journal of Applied Physiology and Occupational Physiology·J F GautierP J Lefèbvre
Nov 13, 2001·American Journal of Respiratory and Critical Care Medicine·P TirakitsoontornD M Cooper
Jan 1, 1998·American Journal of Human Biology : the Official Journal of the Human Biology Council·Nancy BermanDan M Cooper
Jul 1, 1992·The American Journal of Physiology·J A RomijnR R Wolfe
Jul 27, 1999·Respiration Physiology·N PanteleevD Massicotte

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